Which Drugs Cause A Change In Urine Color?

In our latest question and answer, the pharmacist discusses medications that are associated with a change in urine color.


I am hunting for a cause for a change in urine color. It is now a dark yellow and I am not dehydrated. Could 15 migraines in 2 months, for which I needed 15 rizatriptan pills, be the cause?

Asked by Honor On Sep 03, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 03, 2019
different medicine drugs, pills, tablets. pharmaceutical medicine pills


Maxalt (rizatriptan) has not been reported as causing a change in urine color, unfortunately.

However, there are a number of medications that can change urine color, so if you are taking anything in addition to Maxalt, there could be another culprit.

Drugs Associated With Urine Color Change

It can be quite startling to notice a change in your usual urine color, especially if the color is something unusual, like orange, brown or blue.

When a medication you take is the culprit, it is most often simply a harmless effect of the drug and not indicative of anything serious.

Nevertheless, a change in urine color could also be indicative of an underlying medical condition...especially if you haven't started a new medication recently or the color of your urine hasn't changed back to normal after stopping your medication.

The following chart lists many prescription drugs that are associated with a change in urine color.

Final Words

Even if you are taking a medication associated with a change in urine color, if it has turned red or yellow, it is a good idea to discuss the situation with your doctor anyway.

For example, red urine can be indicative of the presence of blood (which could be for a number of reasons) and yellow urine may mean there is something wrong with your liver.

Remember, if you are not taking a medication associated with a change in urine color, or stopping your medication doesn't make the unusual urine color return to normal, be sure to see your doctor.

Sorry we aren't able to provide a definitive answer to your situation! Let us know if we can provide any additional information for you.


  • Several drugs are associated with a change in urine color including nitrofurantoin (brown), rifampin (red) and promethazine (blue/green).

  • References
    1. Drugs that induce changes in urine color. PubMed
    2. Thirty-three drugs that discolor urine and/or stools. PubMed
    3. [Abnormal coloring of the urine]. PubMed
    4. [Color changes in the urine]. PubMed
    5. Abnormal urine color. PubMed

    About the Pharmacist

    Dr. Brian Staiger Pharm.D

    Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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