Methocarbamol


Description

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[

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Pharmacology

Indication

Methocarbamol tablets and intramuscular injections are indicated in the United States as an adjunct... Read more

Pharmacodynamic

Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action.[ Read more

Mechanism of action

The mechanism of action of methocarbamol is thought to be dependant on its central nervous system de... Read more

Absorption

The time to maximum concentration is 1.1 hours for both healthy patients and those on hemodialysis.[... Read more

Protein binding

Methocarbamol is 46-50% protein bound in healthy patients and 47.3-48.9% protein bound in hemodialys... Read more

Volume of distribution

Volume of distribution data in humans is scarce. In horses, the volume of distribution is 515-942mL/... Read more

Clearance

0.2-0.8L/h/kg.[ Read more

Half life

The elimination half life is 1.14 hours in healthy subjects and 1.24 hours in subjects with renal in... Read more

Route of elimination

In humans the majority of the dose is eliminated in the urine.[ Read more

Toxicity

Overdose of methocarbamol may be associated with alcohol and other central nervous system depressant... Read more


Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Hypotension US
Flushing US
Bradycardia US
Headache US
Fever US
Angioneurotic Edema US
Anaphylactic Reaction US
Drowsiness US
Insomnia US
Dizziness US
Lightheadedness US
Confusion US
Diplopia US
Hypersensitivity reactions US
Amnesia US
Vomiting US
Leukopenia US
Cholestatic jaundice US
Nausea US
Dyspepsia US
Jaundice US
Syncope US
Thrombophlebitis US
Pruritus US
Metallic taste US
Urticaria US
Rash US
Blurred vision US
Vertigo US
Nasal Congestion US
Conjunctivitis US
Nystagmus US
Mild muscular incoordination US
Seizures US
Sedation US

Contraindications

  • Route:
    • Intramuscular
    • Intravenous
  • Dose Form:
    • Injection
  • Recommended Actions:
    • Avoid
  • Regions: US
  • Patient Conditions:
      • Name: Renal Impairment
      • Drugbank Id: DBCOND0031781
  • Route:
    • Intramuscular
    • Intravenous
    • Oral
  • Dose Form:
    • Injection
    • Tablet
  • Hypersensitivity:
    • true
  • Recommended Actions:
    • Avoid
  • Regions: US

Food Interactions

  • Avoid alcohol.
  • Take without regard to meals.

Interactions

Type in a drug name to check for interaction with Methocarbamol

The risk or severity of adverse effects can be increased when Methocarbamol is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with 4-Bromo-2,5-dimethoxyamphetamine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with 4-Methoxyamphetamine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with 5-methoxy-N,N-dimethyltryptamine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with 7-Nitroindazole.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Acepromazine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Aceprometazine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Acetazolamide.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Acetophenazine.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Acetylglycinamide chloral hydrate.
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Adinazolam.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Adipiplon.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Agomelatine.
The risk or severity of adverse effects can be increased when Ajulemic acid is combined with Methocarbamol.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Alaproclate.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Alcuronium.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Alfaxalone.
The risk or severity of adverse effects can be increased when Methocarbamol is combined with Alfentanil.

References

  • 1 . Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G: Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol. 1990;39(2):193-4. [PubMed: 2253675]
  • 2 . Bruce RB, Turnbull LB, Newman JH: Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci. 1971 Jan;60(1):104-6. [PubMed: 5548215]
  • 3 . Witenko C, Moorman-Li R, Motycka C, Duane K, Hincapie-Castillo J, Leonard P, Valaer C: Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P T. 2014 Jun;39(6):427-35. [PubMed: 25050056]
  • 4 . Crankshaw DP, Raper C: Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol. 1970 Jan;38(1):148-56. doi: 10.1111/j.1476-5381.1970.tb10343.x. [PubMed: 5413283]
  • 5 . Muir WW 3rd, Sams RA, Ashcraft S: The pharmacology and pharmacokinetics of high-dose methocarbamol in horses. Equine Vet J Suppl. 1992 Feb;(11):41-4. [PubMed: 9109959]
  • 6 . Authors unspecified: Methocarbamol-A New Lissive Agent. Can Med Assoc J. 1958 Dec 15;79(12):1008-9. [PubMed: 20325834]
  • 7 . O'DOHERTY DS, SHIELDS CD: Methocarbamol; new agent in treatment of neurological and neuromuscular diseases. J Am Med Assoc. 1958 May 10;167(2):160-3. [PubMed: 13538683]
  • 8 . FDA Approved Drug Products: Robaxin [Link]
  • 9 . FDA Approved Drug Products: Robaxin Intramuscular Injection [Link]
  • 10 . Pfizer Canada: Robax [Link]

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