Description

Simple

A medication used to treat some inflammatory bowel diseases and types of arthritis.

Clinical

An anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis.

Overview

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Pharmacology

Indication

For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.

Pharmacodynamic

Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.

Mechanism of action

The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

7.5 ± 1.6 L

Clearance

1 L/h [IV administration]

Half life

5-10 hours

Route of elimination

The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Porphyria
      • Drugbank Id: DBCOND0008396
  • Regions: US
  • Patient Conditions:
      • Name: Intestinal or urinary obstruction
      • Drugbank Id: DBCOND0108011

Food Interactions

  • Drink plenty of fluids. Inadequate fluid intake is associated with crystalluria and stone formation.
  • Take with food.

Interactions

Type in a drug name to check for interaction with Sulfasalazine
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(6R)-Folinic acid
The serum concentration of (6R)-Folinic acid can be decreased when it is combined with Sulfasalazine.
(6S)-5,6,7,8-tetrahydrofolic acid
The serum concentration of (6S)-5,6,7,8-tetrahydrofolic acid can be decreased when it is combined with Sulfasalazine.
(R)-warfarin
The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with (S)-Warfarin.
1-benzylimidazole
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 1-benzylimidazole.
2-Methoxyethanol
The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 2-Methoxyethanol.
2,4-thiazolidinedione
Sulfasalazine may increase the hypoglycemic activities of 2,4-thiazolidinedione.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarin
The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of hypertension can be increased when Sulfasalazine is combined with 5-methoxy-N,N-dimethyltryptamine.
5-methyltetrahydrofolic acid
The serum concentration of 5-methyltetrahydrofolic acid can be decreased when it is combined with Sulfasalazine.
9-(N-methyl-L-isoleucine)-cyclosporin A
The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abacavir
Sulfasalazine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abatacept
The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Abatacept.
Abciximab
The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Abciximab.
Abediterol
The risk or severity of hypertension can be increased when Sulfasalazine is combined with Abediterol.
Abemaciclib
Sulfasalazine may decrease the excretion rate of Abemaciclib which could result in a higher serum level.