Chloroquine


Description

The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.

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Pharmacology

Indication

For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale... Read more

Pharmacodynamic

Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria exce... Read more

Mechanism of action

The mechanism behind the plasmodicidal action of chloroquine is not completely certain. Like other q... Read more

Absorption

Completely absorbed from gastrointestinal tract

Protein binding

~55% of the drug in the plasma is bound to nondiffusible plasma constituents

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

1-2 months

Route of elimination

Excretion of chloroquine is quite slow, but is increased by acidification of the urine.

Toxicity

Information currently not available.


Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Weakness and atrophy of proximal muscle groups US
Varying Reports
Maculopathy US
Varying Reports
Macular Degeneration US
Varying Reports
Irreversible retinal damage US
Varying Reports
Visual disturbances US
Varying Reports
Nyctalopia US
Varying Reports
Scotomatous vision US
Varying Reports
Temporal scotomas US
Varying Reports
Tinnitus US
Varying Reports
Reduced hearing US
Varying Reports
Diarrhea US
Varying Reports
Vomiting US
Varying Reports
Erythema multiforme US
Varying Reports
Abdominal Cramps US
Varying Reports
Toxic Epidermal Necrolysis US
Varying Reports
Stevens-Johnson Syndrome US
Varying Reports
Desquamation-type events US
Varying Reports
Exfoliative dermatitis US
Varying Reports
Nerve type deafness US
Varying Reports
Reversible corneal opacities US
Varying Reports
Neuromyopathy US
Varying Reports
Skeletal muscle myopathy US
Varying Reports
Increased liver enzymes US
Varying Reports
Hepatitis US
Varying Reports
Nausea US
Varying Reports
Anorexia US
Varying Reports
DRESS syndrome US
Varying Reports
Angioedema US
Varying Reports
Anaphylactic/anaphylactoid reaction US
Varying Reports
Urticaria US
Varying Reports
Pruritus US
Varying Reports
Lichen planus-like eruptions US
Varying Reports
Skin and mucosal pigmentary changes US
Varying Reports
Pleomorphic skin eruptions US
Varying Reports
Neutropenia US
Varying Reports
Thrombocytopenia US
Varying Reports
Reversible agranulocytosis US
Varying Reports
Aplastic Anemia US
Varying Reports
Pancytopenia US
Varying Reports
Hair discoloration US
Varying Reports
Hair Loss US
Varying Reports
Photosensitivity US
Varying Reports
Torticollis US
Varying Reports
Psychosis US
Varying Reports
Dyskinesia US
Varying Reports
Tongue protusion US
Varying Reports
Polyneuritis US
Varying Reports
Dystonia US
Varying Reports
Convulsive seizures US
Varying Reports
Mild and transient headache US
Varying Reports

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Visual field changes
      • Drugbank Id: DBCOND0107862
  • Regions: US
  • Patient Conditions:
      • Name: Retinal changes
      • Drugbank Id: DBCOND0096337

Food Interactions

  • Take with food to reduce irritation and increase bioavailability.

Interactions

Type in a drug name to check for interaction with Chloroquine

The metabolism of (R)-warfarin can be decreased when combined with Chloroquine.
The metabolism of (S)-Warfarin can be decreased when combined with Chloroquine.
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Chloroquine.
The metabolism of 4-hydroxycoumarin can be decreased when combined with Chloroquine.
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Chloroquine.
The metabolism of 5-androstenedione can be decreased when combined with Chloroquine.
The metabolism of Chloroquine can be decreased when combined with 6-Deoxyerythronolide B.
The metabolism of 6-O-benzylguanine can be decreased when combined with Chloroquine.
The metabolism of Chloroquine can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Chloroquine.
The metabolism of 9-aminocamptothecin can be decreased when combined with Chloroquine.
Chloroquine may decrease the excretion rate of Abacavir which could result in a higher serum level.
The metabolism of Chloroquine can be increased when combined with Abatacept.
The serum concentration of Abemaciclib can be increased when it is combined with Chloroquine.
The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Abexinostat.
The metabolism of Chloroquine can be decreased when combined with Abiraterone.
The metabolism of Chloroquine can be decreased when combined with Acalabrutinib.
Acarbose may decrease the excretion rate of Chloroquine which could result in a higher serum level.
The metabolism of Acebutolol can be decreased when combined with Chloroquine.
Aceclofenac may decrease the excretion rate of Chloroquine which could result in a higher serum level.

References

    Information currently not available.

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