Primaquine


Description

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning...

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Pharmacology

Indication

For the treatment of malaria.

Pharmacodynamic

Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all ca... Read more

Mechanism of action

Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxy... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

3.7-7.4 hours

Route of elimination

Information currently not available.

Toxicity

Information currently not available.


Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Leukopenia US
Varying Reports
Hemolytic Anemia US
Varying Reports
Methemoglobinemia US
Varying Reports
Dizziness US
Varying Reports
QT Interval Prolongation US
Varying Reports
Pruritus US
Varying Reports
Rash US
Varying Reports
Epigastric distress US
Varying Reports
Vomiting US
Varying Reports
Cardiac Arrhythmia US
Varying Reports
Abdominal Cramps US
Varying Reports
Nausea US
Varying Reports

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Acute Illness
      • Drugbank Id: DBCOND0032431
      • Modification Of:
        • Base:
          • Name: Illness
          • Drugbank Id: DBCOND0098876
        • Severity:
          • Includes:
            • acute
  • Regions: US
  • Patient Conditions:
      • Name: Pregnancy
      • Drugbank Id: DBCOND0018394
  • Regions: US
  • Patient Conditions:
      • Name: Rheumatoid Arthritis
      • Drugbank Id: DBCOND0027961
  • Regions: US
  • Patient Conditions:
      • Name: Lupus Erythematosus
      • Drugbank Id: DBCOND0029690
  • Hypersensitivity:
    • false
  • Regions: US
  • Regions: US
  • Patient Conditions:
      • Name: Systemic disease
      • Drugbank Id: DBCOND0108194
  • Patient Conditions Associated With:
      • Name: Granulocytopenia
      • Drugbank Id: DBCOND0006403
  • Regions: US
  • With Categories Coadmin:
      • Name: Myelosuppressive Agents
      • Drugbank Id: DBCAT002716
  • Regions: US
  • With Therapies:
      • Name: Hemolytic agents
      • Drugbank Id: DBCOND0108195
  • Regions: US
  • With Drugs Coadmin:
      • Name: Quinacrine
      • Drugbank Id: DB01103

Food Interactions

  • Take with food to decrease dyspepsia.

Interactions

Type in a drug name to check for interaction with Primaquine

The serum concentration of (R)-warfarin can be increased when it is combined with Primaquine.
The serum concentration of (S)-Warfarin can be increased when it is combined with Primaquine.
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Primaquine.
The metabolism of 4-hydroxycoumarin can be decreased when combined with Primaquine.
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Primaquine.
The metabolism of 5-androstenedione can be decreased when combined with Primaquine.
The metabolism of Primaquine can be decreased when combined with 6-Deoxyerythronolide B.
The metabolism of 6-O-benzylguanine can be decreased when combined with Primaquine.
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Primaquine.
The metabolism of 8-azaguanine can be decreased when combined with Primaquine.
The metabolism of 8-chlorotheophylline can be decreased when combined with Primaquine.
The metabolism of 9-aminocamptothecin can be decreased when combined with Primaquine.
The metabolism of 9-Deazaguanine can be decreased when combined with Primaquine.
The metabolism of 9-Methylguanine can be decreased when combined with Primaquine.
The metabolism of Primaquine can be increased when combined with Abatacept.
The serum concentration of Abemaciclib can be increased when it is combined with Primaquine.
The risk or severity of QTc prolongation can be increased when Primaquine is combined with Abexinostat.
The serum concentration of Primaquine can be increased when it is combined with Abiraterone.
The metabolism of Primaquine can be decreased when combined with Acalabrutinib.
The metabolism of Acebutolol can be decreased when combined with Primaquine.

References

  • 1 . Mihaly GW, Ward SA, Edwards G, Nicholl DD, Orme ML, Breckenridge AM: Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size. Br J Clin Pharmacol. 1985 Jun;19(6):745-50. [PubMed: 4027117]
  • 2 . ALVING AS, ARNOLD J, HOCKWALD RS, CLAYMAN CB, DERN RJ, BEUTLER E, FLANAGAN CL: Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine. J Lab Clin Med. 1955 Aug;46(2):301-6. [PubMed: 13242948]
  • 3 . Hill DR, Baird JK, Parise ME, Lewis LS, Ryan ET, Magill AJ: Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I. Am J Trop Med Hyg. 2006 Sep;75(3):402-15. [PubMed: 16968913]
  • 4 . Cohen RJ, Sachs JR, Wicker DJ, Conrad ME: Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam. N Engl J Med. 1968 Nov 21;279(21):1127-31. [PubMed: 5686480]
  • 5 . Coleman MD, Coleman NA: Drug-induced methaemoglobinaemia. Treatment issues. Drug Saf. 1996 Jun;14(6):394-405. [PubMed: 8828017]
  • 6 . Taavitsainen P, Juvonen R, Pelkonen O: In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug Metab Dispos. 2001 Mar;29(3):217-22. [PubMed: 11181487]
  • 7 . Bapiro TE, Andersson TB, Otter C, Hasler JA, Masimirembwa CM: Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42. Epub 2002 Oct 2. [PubMed: 12451431]
  • 8 . CYP1A2 CTEP document [File]

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