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Zyrtec With Children's Robitussin DM

There is no drug interaction between Zyrtec (cetirizine) and Children's Robitussin DM.


Is it ok for my 9 year old to take Zyrtec and Children’s Robitussin DM together?

Asked by chill516 On Feb 05, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 07, 2019


Yes, the combination of Zyrtec (cetirizine) and Children's Robitussin DM (guaifenesin; dextromethorphan) is safe to take. There is no interaction between the two medications.

Detailed Look

All three active ingredients in these products are in different medication classes and do not interfere with one another:

  • Zyrtec contains cetirizine, a second-generation antihistamine, which is used for the treatment of perennial and seasonal allergies. It is also useful in the treatment of hives.
  • Dextromethorphan, one of the ingredients in Children's Robitussin DM, is a cough suppressant that can reduce the cough reflex and help to ease a sore throat.
  • Guaifenesin, the other ingredient in Children's Robitussin DM, is an expectorant, helping to thin and loosen mucous secretions.

It's always a smart idea to look into potential drug interactions with taking multiple products, especially when any of them are 'combination' products, like Children's Robitussin DM. One of the most common causes of overdosing is from consuming the same drug in multiple products.

Fortunately, Zyrtec and Children's Robitussin DM do not contain any of the same drug ingredients and are perfectly safe to take together.

Zyrtec With Robitussin DM No Drug Interaction

While we're on the subject of Children's Robitussin DM, there is also no interaction between regular (i.e., non-children's) Robitussin DM and Zyrtec.

Robitussin DM for adults contains the same ingredients as Children's Robitussin DM, in equal concentrations. The measuring device and the recommended dosage are the differences.

Children's Robitussin DM (Per 5mL Dose)

  • Dextromethorphan HBr 5 mg
  • Guaifenesin 100 mg

Adult Robitussin DM (Per 20 mL Dose)

  • Dextromethorphan HBr 20 mg
  • Guaifenesin 400 mg
  • Elsevier ClinicalKey: Dextromethorphan; Guaifenesin (Accessed 2/06/19)
  • Elsevier ClinicalKey: Cetirizine (Accessed 2/06/19)
  • Robitussin Manufacturer Website

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Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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