Why To Take Fenofibrate With Water

In our latest question and answer, the pharmacist discusses why fenofibrate should be taken with water.

Question

I take Fenofibrate and the instructions say to take it with a full glass of water. Do you know why? I found myself unable to get a full glass of water, so I skipped my dose. I’m wondering if it would make me sick to take it without water? Or is it just less effective? Thanks

Asked by L.. On May 02, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 04, 2018

Fenofibrate should be taken with a full glass of water for a few reasons. Perhaps most notably is that it eases to process of swallowing and reduces potential esophageal irritation. Many medications are known to cause what esophagitis, fenofibrate included, when they are not taken with enough water, or when individuals lie down soon after taking a dose by mouth.


The exact incidence of esophagitis with fenofibrate isn't known, but has been reported in clinical trials. As stated above, taking your dose of fenofibrate with a full glass of water will help to avoid or reduce the chances of esophagitis occurring.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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