Using Gripe Water With Zantac (Ranitidine)

In our latest question and answer, the pharmacist discusses whether or not it is safe to use gripe water with Zantac (ranitidine).


Can I give my baby gripe water along with Zantac (ranitidine)?

Asked by Emily On Feb 25, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 27, 2018

Gripe water is one of the most commonly used over the counter products to treat for colic in infants. Unfortunately, the term 'gripe water' doesn't indicate a specific product or ingredient. In other words, 'gripe water' does not refer to a single standardized formula.

There are hundreds of products on the market today that are listed as 'gripe water', and most contain different ingredients. 

This can make it difficult to discern potential drug interactions with gripe water products. However, most gripe water products are safe to use with Zantac (ranitidine) and there are generally no interactions reported between the two.

Gripe Water Information

Gripe water was invented in 1851 by a pharmacist named William Woodward. At it's creation in the mid 1800's, 'Gripe Water' contained a relatively high alcohol percentage (as high as 9%), a large amount of sugar as well as various herbs. Today, most, if not all gripe water products contain no alcohol. In addition, most contain little sugar. A history on of gripe water can be found here.

Most gripe water products today contain various herbs and often sodium bicarbonate. The herbs included in gripe water are commonly used nausea relieving herbs such as ginger and fennel. Sodium bicarbonate is often listed as an inactive ingredient but may play a role in neutralizing stomach acid in infants that suffer from GERD (gastroesophageal reflux disease).

Below are the nutrition facts for a popular gripe water products, 'Mommy's Bliss'. This is a good example of the ingredients contained in many gripe water products:

Interaction Between Gripe Water And Ranitidine

The ingredients in this product are mostly consistent with the majority of 'gripe water' products in that it contains no alcohol, no sugar, various herbs and sodium bicarbonate.

Using Gripe Water With Zantac (Ranitidine)

There are no reported interactions with most gripe water products and Zantac (ranitidine). Below is a list of ingredients contained in common gripe water products that are safe to use with ranitidine (i.e. no drug interactions):

  • Sodium bicarbonate
  • Ginger
  • Fennel
  • Lemon oil
  • Chamomile
  • Cinnamon oil
  • Clove oil
  • Dill
  • Galacto-oligosaccharides


You can feel confident that most gripe water products are safe to use with Zantac (ranitidine). There are no reported drug interactions between many of the commonly used ingredients in gripe water and Zantac (ranitidine). 

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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