Taking Zyrtec-D With Mucinex DM

In our latest question and answer, the pharmacist discusses taking Zyrtec-D and Mucinex DM together.


Can Zyrtec-D be taken with Mucinex DM (Dextromethorphan HBr 20 mg; Guaifenesin 400 mg)?

Asked by Akt On Apr 19, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 20, 2019
Zyrtec On Shelf With Text- Zyrtec With Mucinex DM


Yes, Zyrtec-D can safely be taken with Mucinex DM. None of the active ingredients in either medication are known to interact with each other.

In-Depth Look

When discussing potential interactions, it is important to break down all of the active ingredients of the drugs in question.

Zyrtec-D contains two active ingredients:

Mucinex DM also contains two active ingredients:

Cetirizine is a second-generation antihistamine, which differ from first-generation antihistamines (like Benadryl) in many respects. Second-generation antihistamines have a longer duration of action (around 24 hours vs. 4 to 6) and lack significant sedative effects.[1]

Pseudoephedrine is a nasal decongestant and the active ingredient in Sudafed. Pseudoephedrine must be purchased behind the pharmacy counter as a required per the Combat Methamphetamine Epidemic Act of 2005.[2]

Guaifenesin is an expectorant, which helps to thin and loosen mucus secretions in the airway. Thinned mucus secretions are easier to expectorate.[3]

Dextromethorphan is a cough suppressant, which works in the 'cough center' of the brain, reducing the sensation to cough.[4]

As stated above, there are no known interactions between any of these active ingredients.

In fact, you'll find many of them combined in single products. For example, 'Mucinex Fast-Max', in addition to acetaminophen, contains guaifenesin, dextromethorphan, and phenylephrine (a decongestant similar to pseudoephedrine).

There are no products unfortunately that combine all four, so you will need to take at least two (like Zyrtec-D and Mucinex DM).

Final Words

It is always a good idea to look into potential interactions, especially when it involves numerous drugs or when you take prescription medication.

As it concerns Zyrtec-D and Mucinex DM, they are safe together.

  1. ^ Elsevier ClinicalKey: Cetirizine Monograph. ClinicalKey
  2. ^ Elsevier ClinicalKey: Pseudoephedrine Monograph.ClinicalKey
  3. ^ Elsevier ClinicalKey: Guaifenesin Monograph. ClinicalKey
  4. ^ Elsevier ClinicalKey: Dextromethorphan Monograph. ClinicalKey

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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