Taking Wellbutrin With Hydrocodone & Morphine

In our latest question and answer, our pharmacist discusses whether or not there is a drug interaction between Wellbutrin and various opioid pain medications.


What are your thoughts on taking or adding Wellbeturin while on pain medications? I've be on pain medication for years and now I'm trying to quit smoking.I take Ms Contin and Norco daily.. Should I be concerned about the chance of these together increasing any side affects? Any information will be appreciated.

Asked by Granny55 On Nov 06, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 07, 2017

Wellbutrin (buprorpion) is typically considered OK to take along with most pain medications, including opioids such as Norco (hydrocodone/acetaminophen) and MS Contin (morphine sulfate). There is no reported drug interaction between Wellbutrin and those pain medications.

Having said that, there is a precaution with the combination if you have have a seizure disorder, or have a history of seizures. High doses of opioids are associated with an increased risk of seizure. In addition, It is well documented that Wellbutrin lowers the seizure threshold. Theoretically, combining high doses of Wellbutrin and opioids increases seizure risk. In general however, if you are taking appropriately prescribed doses and have no history of seizures, the combination should be relatively safe.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

Recent Questions