Taking Tylenol With Medrol (methylprednisolone)

In our latest question and answer, our pharmacist discusses whether or not there is a drug interaction between Tylenol & Medrol (methlprednisolone).

Question

Can Tylenol Arthritis be taken with methyIPREDNIsolone?

Asked by Harmony On Nov 02, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 02, 2017

Yes, the combination of Tylenol (acetaminophen) and Medrol (methylprednisolone) may be taken together. There is no drug interaction between the two.


Tylenol Arthritis is simply Tylenol (acetaminophen) at a higher dose. Each tablet of Tylenol Arthritis contains 650 mg of acetaminophen so there is no concern regarding using Tylenol Arthritis with Medrol (methylprednisolone) either.


In terms of over the counter analgesics to avoid, there is a moderate interaction between Medrol (methylprednisolone) and Advil (ibuprofen). Although many people are put on the combination of the two for certain indications, prolonged use should be avoided. The combination can increase the risk of certain GI problems such as nausea and ulcers.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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