Taking Tylenol With Hydrocodone/APAP
Tylenol should generally not be taken with hydrocodone/acetaminophen products as the active ingredient in Tylenol is acetaminophen.
Can a person take Tylenol and hydrocodone/acetaminophen 7.5-325 together?
Taking Tylenol with hydrocodone/acetaminophen products is not recommended. This represents a duplication in therapy as the active ingredient in Tylenol is acetaminophen.
Taking both Tylenol and hydrocodone/acetaminophen simply increases your dose of acetaminophen, increasing your risk of overdose and adverse effects.
Tylenol With Acetaminophen
It is extremely important to be aware of all the active ingredients in the medication you are taking, especially when it comes to combination products.
Hydrocodone/acetaminophen is a good example of a combination product. It contains both the opioid analgesic hydrocodone and acetaminophen. The most common amount of acetaminophen contained in hydrocodone products is 325 mg per pill/capsule.
Although acetaminophen has a long history of safe and effective use, unintentional or intentional misuse is the number one cause of acute hepatic failure in the United States (1). It is also one of the most common drugs seen in cases of accidental child ingestion (2).
Acetaminophen Dosing Limits
The maximum daily dose of acetaminophen is set at 4,000 mg per day, but this generally should only be done on the recommendation of your doctor.
If you are taking multiple products that contain acetaminophen, it is important to keep track of your daily ingestion of the drug.
Your doctor may recommend taking Tylenol (acetaminophen) for mild pain and only taking your hydrocodone/acetaminophen product as needed for severe pain. As discussed above, since your hydrocodone product does contain acetaminophen, be sure not to go over the maximum daily dose.
Acetaminophen, often abbreviated as APAP, is used as a pain reliever and fever reducer. It does not have anti-inflammatory effects and doesn't affect blood platelets like other over the counter pain relievers such as ibuprofen and naproxen.
Oral doses of acetaminophen reach peak concentrations within 30 to 60 minutes, and will last around four to six hours per dose.
Acetaminophen is generally considered to be safe and effective. However, as described above, misuse can cause acute liver failure.
More information about acetaminophen can be found here:
Hydrocodone is an opioid agonist and is most commonly prescribed in combination with acetaminophen (e.g. Vicodin, Norco, hydrocodone/acetaminophen).
Hydrocodone is also available as a single ingredient in products such as Zohydro ER.
Hydrocodone works by acting as a mu-receptor opioid agonist, which alters the perception of pain in the central nervous system.
Hydrocodone may be taken with or without food, but food may reduce nausea. It has an onset of action within 10-30 minutes and duration of action around 4 to 8 hours for immediate release products.
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