Taking Sudafed PE And Augmentin Together

In our latest question and answer, the pharmacist discusses whether or not Sudafed PE and Augmentin can be safely taken together.


Is it ok to take Sudafed PE and Amox-Clav together?

Asked by Danielle On May 13, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 14, 2018

There is no interaction between Sudafed PE (phenylephrine) and Amoxicillin-Clavulanate (Augmentin), so they can be taken safely together.


According to the prescribing information, Amox-Clav is an antibiotic containing a penicillin that is used for a variety of infections, including sinus, skin, urinary tract, and lower respiratory infections.

Common Side Effects

  • Diarrhea
  • Nausea
  • Skin rash
  • Itching
  • Vomiting
  • Vaginitis

Drug Interactions

  • Warfarin: INR monitoring recommended since penicillin antibiotics may increase the INR and risk of bleeding when on warfarin
  • Probenecid: may decrease excretion of antibiotic and cause increased concentrations of Amox-Clav; not recommended together
  • Allopurinol: increases potential for developing rash
  • Oral contraceptives (birth control): may reduce the effectiveness of oral contraceptives through decreasing absorption
    • Another form of contraception should be used along with the oral contraceptive to reduce risk of pregnancy

Warnings and Cautions

  • Hypersensitivity reactions (allergic reactions) may occur and may be severe
    • Tell your healthcare provider and pharmacist if you have a history of allergic reaction to beta-lactam antibiotics (penicillins, cephalosporins) before use
  • Hepatitis / cholestatic jaundice has been reported and hepatic function should be considered before use
  • Clostridium difficile (C. diff) diarrhea may occur and patients should make sure to stay hydrated if experiencing diarrhea and tell a healthcare provider if having severe or bloody diarrhea
  • Amox-Clav chewable tablets and suspensions contain phenylalanine and should not be used in phenylketonurics


  • Hypersensitivity to any of the ingredients or penicillins
  • Hepatic dysfunction / cholestatic jaundice


  • Suspensions of this medication should be refrigerated and if there is any suspension left over after the recommended course is finished, it should be discarded
  • Finish the whole course of antibiotics unless told otherwise by a healthcare professional, as unfinished antibiotic therapy can cause bacterial resistance
  • Although Amox-Clav can be taken with or without food, taking the antibiotic with food may help decrease stomach upset

Sudafed PE

According to the prescribing information, Sudafed PE is a decongestant used to relieve congestion and pressure caused by allergies or colds.

Side Effects

  • Talk to a healthcare professional these symptoms persist or are severe:
    • Dizziness
    • Insomnia
    • Nervousness
    • Increased blood pressure

Warnings and Cautions

  • Consult a healthcare provider before taking Sudafed PE or other products containing phenylephrine or pseudoephedrine if you have:
    • Heart disease
    • High blood pressure
    • Diabetes
    • Thyroid problems
    • Enlarged prostate gland and trouble urinating
  • Do not use if you are taking a monoamine oxidase inhibitor (MAOI), as it can cause a significant and potentially dangerous increase in blood pressure
    • Examples of MAOIs: rasagiline (Azilect), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate)
  • Certain forms of phenylephrine that contain aspartame contain phenylalanine and should not be used in phenylketonurics


  • Do not take more than 6 tablets of the phenylephrine 10 mg (60 mg) in 24 hours
  • If symptoms do not resolve within 7 days, stop taking Sudafed PE and see a healthcare professional
  • Products with phenylephrine are not approved for children less than 4 years of age; however, a healthcare provider should be consulted before use in children less than 12 years of age

About the Pharmacist

Dr. Anna Staudt Pharm.D

Dr. Anna Staudt graduated in 2017 with a Doctor of Pharmacy degree. She is completing a pharmacy fellowship focused on ambulatory care. Her current practice site is at a Federally Qualified Health Center (FQHC) where she deals with the underserved.

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