Taking Penicillin With Cymbalta And Neurontin

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Cymbalta and Neurontin.


Hi I am taking Penicillin 4 times a day for the next 4 days because I am getting my wisdom teeth out. I am also on 90 mg of Cymbalta and 300 mg of Neurontin Is it safe?

Asked by Han On Jun 07, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jun 08, 2018

There are no known interactions when taking penicillin and Cymbalta together. However, caution is advised when taking penicillin and Neurontin together. This is because penicillin can lower the body's threshold to have a seizure, which may alter the seizure control treatment of Neurontin (if that is what you are taking it for).

The research that has been found supports only a low evidence of antibiotics, like penicillin, causing a seizure.The actions taken may involve monitoring any changes of seizure symptoms while taking the penicillin short term to prevent an infection. Make sure you inform your primary doctor about the penicillin prescription you have been prescribed. If you have additional risk factors for having a seizure you should not take the penicillin with the Neurontin. 

Learn more about the medications Neurontin and penicillin below.

Neuronin (Gabapentin)

Neurontin (gabapentin) is an analgesic and anti-epileptic medication that has many uses, but is commonly used to relieve neuropathic pain and prevent seizures. Gabapentin can be taken with or without food. You should not stop taking gabapentin unless instructed by your doctor according to a tapering schedule. Gabapentin may alter your mood or disposition, which is why you and family should monitor for depression or behavior changes. 


Penicillin VK is an oral penicillin and potassium antibiotic that is given to prevent and treat bacterial infections. A common symptoms when taking an antibiotic is diarrhea which will stop when you stop taking the medication. Make sure to take the full course of your antibiotic treatment to prevent any infection after the teeth removal.

About the Pharmacist

Dr. Jennifer Oliver Pharm.D

Dr. Jennifer Oliver is a licensed immunizing pharmacist in Florida. She graduated from the University of South Florida with a Doctor of Pharmacy Degree in 2015. Other than her passion for pharmacy, she loves traveling and meeting new people.

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