Taking Omeprazole With Propranolol

In our latest question and answer, the pharmacist discusses whether or not propranolol can be taken with omeprazole.


I take Propranolol 80 mg. I take it to suppress the extra heart beat I have (beta blocker). I need to take Omeprazole for my stomach ulcers. I take Prop at night before I sleep. If I take the Omep during the day, is it safe? Can the two be taken together? How far apart must I take them, if not?

Asked by Chrissy On Jun 01, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jun 12, 2018

Propranolol StructureThere are no known interactions between propranolol and omeprazole. They are considered safe to take together.

It is always a good idea to look into potential interactions when omeprazole is involved as it alters the pH of the stomach, which can significantly affect the absorption of many drugs. Propranolol absorption fortunately, is not dependent on pH and therefore may be safely taken with omeprazole.

It is important to note however that propranolol is generally recommended to take with food as food (specifically high in protein) can increase the bioavailability (rate and extent of absorption) by nearly 50% according to the prescribing information for the drug.

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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