Taking NyQuil With Medrol (Methylprednisolone)

There is no know drug interaction between NyQuil and Melatonin.


Can I take 4mg Methylprednisolone with Nyquil Cold and flu? I was prescribed the steroid for a virus, but ended up with a nasty cough.

Asked by Jay On Nov 30, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Dec 14, 2018

Medrol (methylprednisolone) can safely be taken with NyQuil Cold and Flu as there are no known interactions between them.

In fact, the sedative effects of NyQuil may help to offset some of the most commonly reported side effects of Medrol, such as anxietyinsomnia, and restlessness.

It is important to remember that NyQuil is a multi-ingredient product and therefore, you need to take them all into account as it concerns potential drug interactions.

NyQuil Cold and Flu contains:

  • Acetaminophen
  • Doxylamine
  • Dextromethorphan
  • Phenylephrine (only in NyQuil Severe)

None of the ingredients in NyQuil, or NyQuil Severe, interact with Medrol.

Answer Summary

There are no drug interactions between Medrol (methylprednisolone) and NyQuil Cold and Flu. They are safe to take together.

About NyQuil

NyQuil is a combination ingredient cold/flu medication.

It contains:

  • Acetaminophen, a pain reliever and fever reducer. Acetaminophen is the active ingredient in Tylenol.

  • Doxylamine, a sedating antihistamine, similar to Benadryl (diphenhydramine).

  • Dextromethorphan, a cough suppressant.

  • Phenylephrine, a nasal decongestant.

Several other varieties of NyQuil are available as well, all of which can be seen on the manufacturer website.

NyQuil begins working about 15 to 30 minutes after taking a dose, and has a typical duration of action around 4-6 hours.

About Medrol

Medrol (methylprednisolone) is a corticosteroid, commonly used to treat inflammation of the skin, joints and lungs.

It is used for a wide variety of indications, including:

  • Asthma exacerbations

  • Allergies, including contact dermatitis reaction (e.g. poison ivy)

  • Arthritis

Methylprednisolone is most commonly prescribed in a Dosepak, which follows a 21 tablet dose titration schedule:

  • Day One: 2 tablets (8 mg) before breakfast, 1 tablet (4 mg) after lunch, 1 tablet (4 mg) after supper, and 2 tablets (8 mg) at bedtime.

  • Day Two: 1 tablet (4 mg) before breakfast. 1 tablet (4 mg) after lunch, 1 tablet (4 mg) after supper, and 2 tablets (8 mg) at bedtime.

  • Day Three:  tablet (4 mg) before breakfast, 1 tablet (4 mg) after lunch, 1 tablet (4 mg) after supper, and 1 tablet (4 mg)  at bedtime.

  • Day Four: 1 tablet (4 mg) before breakfast, 1 tablet (4 mg) after lunch, and 1 tablet (4 mg) at bedtime.

  • Day Five: 5th day: 1 tablet (4 mg) before breakfast, and 1 tablet (4 mg) at bedtime.

  • Day Six: 6th day: 1 tablet (4 mg) before breakfast.

Medrol should be taken with food or meals to minimize nausea, indigestion and stomach irritation.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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