Taking Neurontin (Gabapentin) With Ibuprofen

They are considered safe to take together.


Can I take Neurontin, generic name gabapentin, with ibuprofen ?

Asked by Sal On Sep 24, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 24, 2018

There are no drug interactions between ibuprofen (Advil) and gabapentin (Neurontin). Both are types of pain medications, but work differently and treat different types of pain. Below, we will discuss more information about each of these medications.


Information About Gabapentin

Gabapentin reduces anxiety, pain, and seizure activity by binding to receptors in the central nervous system tissues. Gabapentin is structurally related to GABA, a brain chemical that generally has a depressive or slowing effect. The half-life of gabapentin is about 6 hours.

Gabapentin was first approved by the FDA in 1993 for seizures and in 2002 for nerve pain associated with Shingles. Usually the dose for gabapentin is titrated over time to find the right dose and may be given up to three times daily. Gabapentin can cause drowsiness, fatigue, and headache in some patients.


Information About Ibuprofen

NSAIDs work by inhibiting an enzyme known as cyclooxygenase (COX). There are two types of COX, known as COX-1 and COX-2. COX-2 has a more prominent in the inflammation cascade. Ibuprofen is considered non-selective and inhibits both COX-1 and COX-2. Drugs within the NSAID class differ based on the difference in selectivity, which can make a difference in the side effect profile and utility of these drugs.

All NSAIDs, including ibuprofen (Advil), can cause upset stomach, diarrhea, heartburn, and constipation (usually in less than 10% of patients). Also, caution is advised in patients with previous cardiac and GI conditions which may increase risk for worsening their condition. Additionally, caution should be taken while taking other blood thinners like warfarin, apixaban (Eliquis), clopidogrel (Plavix), or heparin products.



While both ibuprofen and gabapentin can be used for pain, these medications work differently and there is no known risk to taking these together. Ibuprofen is typically used to treat a wide variety of ailments including pain, fever, and arthritis. Gabapentin is better for neuropathic pain including fibromyalgia and restless leg syndrome. 

About the Pharmacist

Dr. Kevin Davis Pharm.D

Dr. Kevin Davis is a licensed pharmacist with experience in retail and hospital pharmacy. He graduated from the University of Florida with a Doctor of Pharmacy degree in 2015 and a Master of Healthcare Administration degree from Adventist University in 2017. He is also a Board Certified Pharmacotherapy Specialist since 2016.

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