Taking Mucinex With Eliquis

In our latest question and answer, the pharmacist discusses whether or not Mucinex and Eliquis can be taken together.


I take Eliquis (10 mg per day). Is it OK to take a Mucinex to reduce the discomfort of mucus or phlegm? How many milligrams would be ok?

Asked by David On Apr 01, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 02, 2019

There is no known interaction between Eliquis (apixaban) and Mucinex (guaifenesin). They are considered safe to take together.[1]

Additionally, Mucinex does not affect blood coagulation or alter bleeding time, so it, in most cases, is safe to take with anticoagulants and antiplatelets.

In terms of the dose of Mucinex that is safe to take, you can simply take it as directed per the package directions.

Extended-release Mucinex products can be dosed as:[2]

  • 600 mg to 1,200 mg every 12 hours

Immediate-release Mucinex products can be dosed as:

  • 200 mg to 400 mg every 4 to 6 hours

As stated, it is safe to take with Eliquis, even at the same time.

Drugs available over the counter that you want to avoid with Eliquis are NSAIDs. These include ibuprofen and naproxen. NSAIDs can thin the blood, and increase the risk of bleeding if taken with Eliquis. The prescribing information for the drug specifically mentions avoiding them (unless otherwise directed by your doctor).[3]


There is no drug interaction between Eliquis and Mucinex.

  1. ^ Elsevier ClinicalKey Drug Interaction Report. ClinicalKey (Subscription Required)
  2. ^ Elsevier ClinicalKey Mucinex Monograph. ClinicalKey (Subscription Required)
  3. ^ Eliquis Prescribing Information

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

Recent Questions