Taking Metoprolol & Lisinopril/HCTZ Together

In this article, we discuss taking the combination of lisinopril/hctz & metoprolol together as well as whether or not there are any drug interactions to be concerned of.


Should I be taking metoprolol succinate ER and Lisinopril-hctz together?

Asked by Jim On Oct 28, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Oct 29, 2017

Yes, metoprolol & lisinopril/hydrochlorothiazide can be taken together. There as no drug interactions between the two.

In fact, the combination is recommended for certain indications. 

For example, the  American Society of Hypertension (ASH) recommends the combination of a beta blocker (e.g. metoprolol) along with an ACE-Inhibitor (e.g. lisinopril) for the treatment of coronary artery disease. Thiazide diuretics (e.g. HCTZ) are also a recommended agent. 

When treating uncomplicated hypertension (blood pressure), multiple classes of drugs are a typically added together until blood pressure is adequately controlled. It is not uncommon to see patients on 3 or 4 different classes of blood pressure medications. 

There are many other indications that could call for the combination you are taking and is commonplace. If you have concerns about you current therapy, be sure to bring up your questions to your doctor.

If one of these medications is new for you, be aware that it could cause dizziness and lightheadedness, at least initially. This isn't a drug interaction, but your body is adjusting to a lower blood pressure.

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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