Taking Liverite Liveraide With Lipitor

We answer our latest question regarding taking Liverite Liveraide.

Question

Is it okay to take Liverite Liveraide with my cholesterol medication Lipitor?

Asked by Amy On Sep 20, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 20, 2017
Lipitor Box with Text Overlay

I will try and answer this question as thoroughly as possible but I want to throw out the disclaimer that is often very difficult to give a definitive answer regarding drug-herbal product interactions since they are not well studied.

There simply is not a lot of data out there and the data that is available is typically low-quality evidence. While I can give you some guidance in terms of the information available, I always recommend you reach out to your physician before starting any supplement while taking prescription medication.

What Is In Liverite LiverAid?

Liverrite Liveraide

The first step is to determine the active ingredients of the product in your inquiry. According to the manufacturer website, Liverite Liveraid contains the active ingredient of Milk Thistle (Silymarin). Historically, milk thistle has been used for thousands of years for various disorders of the liver, kidney, and spleen. It has been studied as a treatment for alcoholic liver disease and a number of different types of viral hepatitis.[1][2]

Milk Thistle is one of the most popular supplements on the market and is a component of 100's of products. It is commonly marketed and used for various liver disorders and as a 'liver-protective' supplement. Another term for this is "hepatoprotective". According to available data, it has antioxidant and free radical-scavenging actions and those actions are thought to be an important mechanism for the hepatoprotective effects.

You are not alone in looking to take this supplement. Surveys have shown that almost 30% of patients in the US with chronic hepatic diseases supplement their regimen with milk thistle in addition to their regularly prescribed medications.

LiverAid With Lipitor

In terms of an interaction with Lipitor (atorvastatin), there is little data available.

I could only find one study that researched the subject matter and it tested the effects of silymarin when combined with rosuvastatin (generic Crestor), which is in the same class of medications as Lipitor.

The study showed that while silymarin did inhibit certain aspects of drug metabolism but there was no change in any drug concentrations of rosuvastatin.  The authors concluded that silymarin did not appear to affect rosuvastatin pharmacokinetics (how a drug is absorbed, metabolized etc... in the body).[3]

In conclusion, I found no data regarding a potential interaction but again, there is certainly a limited amount of information available. So while most signs point to it not being an issue to take atorvastatin and milk thistle together,  I always recommend you reach out to your physician before starting any supplement in addition to your medication regimen.

Summary

There is no known interaction between Liverite LiverAid and Lipitor.

References
  1. ^ Liverite Manufacturer Website
  2. ^ Milk thistle (Silybum marianum) for the therapy of liver disease. PubMed
  3. ^ Effect of silymarin supplement on the pharmacokinetics of rosuvastatinPubMed

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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