Taking Cipro (Ciprofloxacin) With Alcohol
Mixing alcohol with antibiotics like Cipro (ciprofloxacin) generally isn't recommended.
I am currently taking Cipro (ciprofloxacin) for a kidney infection and I was wondering if I can drink alcohol on it? I talked to my pharmacist and she said I should just make sure to stay hydrated. Looking for a second opinion.
While there is no direct interaction between ciprofloxacin
(Cipro) and alcohol, it is not recommended to drink while recovering from an
infection. Alcohol can decrease immune function and exacerbate antibiotic side
effects like nausea, diarrhea, and upset stomach. While recovering from an
infection, it is important to stay well hydrated and get plenty of rest.
How Alcohol Is Metabolized:
Alcohol is primarily metabolized via. The byproducts of alcohol include acetaldehyde and acetate and contribute to many of the negative effects.
Genetic variation of these enzymes causes varying degrees of alcohol metabolism—which is why everyone tolerates alcohol differently. This metabolism takes place mostly in the liver. CYP enzymes play a particularly important role in drug metabolism and drug interactions occur via the inhibition or induction of these enzymes. Alcohol does impact CYP enzymes, especially CYP2E1.
Some drugs may cause a “disulfiram-like reaction” when taken
with alcohol. This can cause flushing, nausea, vomiting, and general “hangover
effects”. These drugs inhibit aldehyde dehydrogenase which is crucial in
metabolism of alcohol. Some of these drugs include
Information On Ciprofloxacin:
is a commonly used antibiotic in the fluoroquinolone class and can be used to treat a variety of infections. It is considered to be broad-spectrum antibiotic. Ciprofloxacin is absorbed via the GI tract and is metabolized and eliminated via the liver and kidney. Ciprofloxacin does inhibit CYP1A2 and CYP3A4, but neither of these impact alcohol metabolism.
Ciprofloxacin can cause abdominal pain,
nausea, and diarrhea similar to other antibiotics. Unique side effects for
fluoroquinolones include tendon rupture (especially in the elderly population,
burning/tingling in extremities, and CNS effects.