Taking Cheratussin AC With Prozac (fluoxetine) & Clonazepam
In our latest question and answer, we discuss the potential interaction between Cheratussin AC, Prozac (fluoxetine) & clonazepam.
I was prescribed Cheratussin AC for a bad cough. I currently take: Prozac: 5 mg Adderall: 20 mg 2x a day Lamictal: 200 mg 2x a day Clonazepam: 1 mg as needed.How will this combo affect me? Is it safe?
There are some mild interactions with the drugs you are currently taking and Cheratussin AC, but nothing that would be considered major or a contraindication.
Cheratussin AC is a cough medication that contains two active ingredients, codeine and guaifenesin. It is typically prescribed for short periods of time to help relieve the cough and post nasal drip.
You are taking Prozac (fluoxetine), which is known to decrease the metabolizing ability of a major enzyme in our body known as CYP2D6. Codeine is relatively inactive in our bodies until it is metabolized to its active metabolite, morphine.
Taking fluoxetine with codeine will theoretically reduce the amount of codeine converting into morphine, thus reducing the effect of the drug. While this isn't considered a major drug interaction, the overall effect of Cheratussin AC may be reduced.
You are also taking clonazepam, a benzodiazepine, which can cause sedation and CNS (central nervous system) depression. Adding this to codeine can cause excess sedation and drowsiness. You certainly do not want to operate heavy machinery while taking this combination of medications.
As you are most likely taking Cheratussin AC for a short period of time, it would typically be considered OK to use it with your combination of drugs. However, it is important to be aware of the side effects such as sedation. Taking it at night, when you can stay home, is most likely the best and safest time to use the medication.
If you are concerned about potential interactions, please speak with your pharmacist or prescribing doctor.