Taking Buspar (Buspirone) With Tylenol Sinus

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Buspar and Tylenol Sinus.


I'm taking buspirone for anxiety. I'm having congestion. Is it OK if I take severe sinus medication. It's like Tylenol but generic.

Asked by Amy On Jun 03, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jun 08, 2018

There are no known interactions between buspirone and the active ingredients that are found in Tylenol Sinus Severe Daytime. It would be considered safe to treat the congestion symptoms that you are having with the Tylenol product.

Tylenol Sinus Severe Daytime contains:

  • Acetaminophen (analgesic)
  • Phenylephrine (decongestant)
  • Guaifenesin

Buspar Information

Buspirone (Buspar) an anti-anxiety medication that should not be taken with MAO inhibitors, including linezolis, methylene blue injection, selegiline, rasagiline, and phenelzine

Caution should be used when taking this drugs with other CNS active medications. Avoid taking this medication with grapefruit juice as this could affect the concentration of buspirone that is in the body. This medication commonly causes sedation and dizziness.

About the Pharmacist

Dr. Jennifer Oliver Pharm.D

Dr. Jennifer Oliver is a licensed immunizing pharmacist in Florida. She graduated from the University of South Florida with a Doctor of Pharmacy Degree in 2015. Other than her passion for pharmacy, she loves traveling and meeting new people.

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