Taking Benadryl With Zegerid

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Benadryl (diphenhydramine) and Zegerid


Can you use Zegerid and Benadryl at the same time?

Asked by Paul On May 09, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 09, 2018

There is no known drug interaction between Benadryl and Zegerid. They are considered to be safe to take together.


Zegerid (omeprazole/sodium bicarbonate) is used to treat heartburn and acid reflux. It contains two active ingredients, omeprazole and sodium bicarbonate. Omeprazole is the active ingredient in Prilosec and acts as a "proton pump inhibitor", which blocks the release of gastric acid into the stomach. Sodium bicarbonate, most often known as baking soda, acts as a quick-acting antacid for more immediate relief after taking Zegerid by mouth.


Benadryl is a first generation antihistamine that exerts its effect by blocking the binding of histamine to histamine receptors. Histamine is a molecule that the body releases when it is exposed to an allergen, and is responsible for symptoms like rash, itching and a runny nose.

Benadryl is used to treat a number of allergic reactions, from those as mild as a small rash to something as severe as anaphylaxis. It can also be used to help aid in falling asleep. Some of the most common side effects seen in patients are:

  • Sedation
  • Confusion
  • Constipation
  • Urinary retention

About the Pharmacist

Dr. Hayden Gharibyar

Dr. Hayden Gharibyar is a Doctor of Pharmacy graduate from the University of Colorado. His areas of expertise include pharmacovigilance and drug safety.

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