There is no known drug interaction between Benadryl and Zegerid. They are considered to be safe to take together.


Zegerid (omeprazole/sodium bicarbonate) is used to treat heartburn and acid reflux. It contains two active ingredients, omeprazole and sodium bicarbonate. Omeprazole is the active ingredient in Prilosec and acts as a "proton pump inhibitor", which blocks the release of gastric acid into the stomach. Sodium bicarbonate, most often known as baking soda, acts as a quick-acting antacid for more immediate relief after taking Zegerid by mouth.


Benadryl is a first generation antihistamine that exerts its effect by blocking the binding of histamine to histamine receptors. Histamine is a molecule that the body releases when it is exposed to an allergen, and is responsible for symptoms like rash, itching and a runny nose.

Benadryl is used to treat a number of allergic reactions, from those as mild as a small rash to something as severe as anaphylaxis. It can also be used to help aid in falling asleep. Some of the most common side effects seen in patients are:

  • Sedation
  • Confusion
  • Constipation
  • Urinary retention