Taking Benadryl With Phenazopyridine

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl with Taking Benadryl With phenazopyridine,


I was prescribed Pyridum to help with the pain of a urinary tract infection. I was wondering if it was safe to take with Benadryl.

Asked by Fitzpatrick On May 29, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 29, 2018

Pink PillsPyridium (phenazopyridine) and Benadryl (diphenhydramine) do not have any known drug interactions. They are safe to take together.


Phenazopyridine is used to relieve pain from urination in patients who have inflammation in their urinary tract. It is available by prescription (brand name Pyridium) and over the counter (brand name Azo) in a lower dose.

It works by exerting a local anesthetic effect to the urinary tract. It is often used in conjunction with an antibiotic for treatment for those patients who have been diagnosed with a bladder infection. This medication does not have any antibiotic properties alone.

Headache, dizziness, and stomach upset are the most commonly seen side effects with this medication. It can also turn the patient’s urine orange, and they should be warned of this prior to administration so they are not alarmed if they see this change occur


Benadryl (diphenhydramine) is a "first-generation" antihistamine and is used to treat allergic reactions and is also commonly used as a sleep aid for patients who have difficulty falling asleep.

Sedation and drowsiness are the side effects that are most often seen in patients when they take this medication. Other side effects include constipation, urinary retention, and blurred vision. 

About the Pharmacist

Dr. Hayden Gharibyar

Dr. Hayden Gharibyar is a Doctor of Pharmacy graduate from the University of Colorado. His areas of expertise include pharmacovigilance and drug safety.

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