Mucinex Box With Black Background With Text - With Benadryl


Yes, Benadryl (diphenhydramine) and Mucinex (guaifenesin) may be safely taken together as there is no drug interaction between the two.[1]

In fact, many over the counter products contain both of these ingredients to aid in alleviating various cough and cold symptoms.

What Is Benadryl?

Benadryl (diphenhydramine) is a sedating, first-generation antihistamine and will begin working within 15 to 30 minutes after taking a dose.

Each dose lasts around 4-6 hours, with this time being extended in certain individuals (e.g. the elderly). This is why a 'hangover' effect is more common in older adults.[2]

Benadryl has many uses. Most commonly, it is used for the treatment of allergies and as a sleep aid (due to its sedative effects).

When used for allergies, it not only acts to prevent allergy symptoms (by blocking the binding of histamine to receptors) but also has a drying effect. The drying effect of Benadryl is one of the many 'anticholinergic' properties of the drug. These effects help to clear up a runny nose as well as help to reduce post nasal drip.[3]

What Is Mucinex?

Mucinex (guaifenesin) acts as an expectorant. It helps to loosen and thin mucus sections, making it easier to remove them from the airways.

When you have chest congestion, Mucinex often changes an unproductive cough to a productive one. This can help to soothe an irritated throat.

Mucinex has very few documented drug interactions and is thought to be safe with most prescription and OTC products. In fact, many drug information sources report that Mucinex has no known drug interactions.[4]

Final Words

As mentioned, both Mucinex and Benadryl can be taken together and often are. They are very common ingredients in many over the counter cough/cold products.


There is no drug-drug interaction between Mucinex and Benadryl.

  1. ^ Elsevier ClinicalKey: Interactions. ClinicalKey
  2. ^ Long-term use of diphenhydramine. PubMed
  3. ^ Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models. PubMed
  4. ^ Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections. PubMed