Taking Benadryl With Dayquil

In this article, our pharmacist discusses whether or not you can take Benadryl (Diphenhydramine) with Dayquil.


Can I take Benadryl and Dayquil together?

Asked by Teri On Nov 05, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 05, 2017

Yes, you can take Benadryl (diphenhydramine) and Dayquil together as they do not interact. However, most people take Dayquil to alleviate cough/cold symptoms without sedation and Benadryl would defeat that purpose.

Dayquil contains:

  • Acetaminophen - Pain reliever/fever reducer
  • Dextromethorphan - Cough suppressant
  • Phenylephrine - Nasal decongestant

None of the above ingredients cause sedation and provide effective relief of many cough/cold symptoms. Dayquil is a good option for those who need to be active after administration or operate heavy machinery. 

Benadryl (diphenhydramine) is a sedating antihistamine, that typically produces drowsiness within 30 minutes and can last 4-8 hours.

If you are looking for the benefits of an antihistamine in addition to taking Dayquil, we recommend trying the following antihistamines as they will not cause sedation:

  • Claritin
  • Allegra

If you are looking to for help sleeping while taking Dayquil, try 'Nyquil Severe' instead, as it combines all of the ingredients of Dayquil with the sedating antihistamine doxylamine.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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