Taking Benadryl With Citracal

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between Benadryl and Citracal.


I take a calcium supplement (Citracal). Is it safe to take Benadryl with it? I know calcium can interact with a lot of different medications.

Asked by Murphy On Apr 24, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 24, 2018

There is no drug interaction between Benadryl and Citracal. They are safe to take together.


Benadryl is the brand name for diphenhydramine, a first-generation antihistamine. Benadryl can be used for different reasons but most commonly it is used for seasonal allergies or allergic reactions. Some people take Benadryl to help them sleep, to relieve motion sickness, or to treat symptoms associated with the common cold.

Because it is a “first-generation” antihistamine, this means it is one of the earlier drugs developed in this category of medications. First-generation antihistamines are noted for their sedative effects and short duration of action (~4-6 hours per dose).


Citracal is the brand name for a calcium supplement that contains calcium in a form that is easier for your stomach to absorb compared to other supplemental calcium.

Citracal (available generically as calcium citrate) is available over the counter that and contains 21% elemental calcium. The recommended daily allowance (RDA) of calcium differs depending on age, sex, and other health conditions. While most of your daily calcium intake should come from dietary sources (i.e., milk, cheese, etc.), calcium supplements are available for when dietary intake is inadequate.

Calcium can interact with other medications by reducing their absorption. However, it does not have this effect on Benadryl.


  • There is no drug interaction between Benadryl and Citracal. They can be taken together.

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Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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