Taking Benadryl With Bonine

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl with Bonine.


I use Bonine for my motion sickness problems. Can I use Benadryl?

Asked by Connor On Apr 28, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 28, 2018

Benadryl and Bonine do not have a typical drug interaction, but as both of these medications contain an antihistamine and there is good potential for an increase in side effects that each perspective medication. Since these two medications work in the same way, there is typically no added benefit in taking both at the same time, and there is an increase in the potential of the side. Taking both together isn't usually recommended.


Benadryl (diphenhydramine) is a first generation antihistamine that works by blocking the activity of histamine. Histamine is released during allergic reactions, which is why Benadryl is typically used during an allergic reaction.

Benadryl has a relatively short duration of action, around 4 to 6 hours, and can cause considerable sedation. For this reason, it is often used as a night time sleep aide. In addition to sedation, Benadryl is known to cause the following side effects:

  • Sedation
  • Dry mouth
  • Dry eyes
  • Constipation


Bonine contains the active ingredient meclizine, an antihistamine not unlike Benadryl. It works to block histamine and can be effective in reducing nausea experienced during abrupt motion changes. Patients most commonly develop drowsiness, urinary retention as well as headaches when they take this medication. Because of its potential to cause drowsiness this medication should also be used with caution in the elderly population.


  • Benadryl can safely be taken with Bonine. There is no drug interaction between the two medications.

About the Pharmacist

Dr. Hayden Gharibyar

Dr. Hayden Gharibyar is a Doctor of Pharmacy graduate from the University of Colorado. His areas of expertise include pharmacovigilance and drug safety.

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