Taking Benadryl (Diphenhydramine) With Oxycodone

In this article, our pharmacist discusses whether or not you can combine Benadryl (diphenhydramine) with oxycodone.


Can you take Benadryl with oxycodone?

Asked by Manu On Nov 03, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 03, 2017

In general, it is not recommended to combine Benadryl (diphenhydramine) and oxycodone, especially if oxycodone is a new medication for you.

Oxycodone, by itself, can cause respiratory depression as well as depression of the CNS (Central Nervous System). Combining Benadryl (diphenhydramine), a sedating first generation antihistamine, can accentuate these effects.

There have been reports of significant drops in blood pressure, excess sedation as well as respiratory depression on the combination. You certainly do not want to mix Benadryl (diphenhydramine), oxycodone and alcohol together.

Having said all that, the combination of Benadryl (diphenhydramine) and oxycodone can be used in some situations.

Chronic use of oxycodone leads to tolerance to it's effects. Typically, once your level of tolerance to the depressant effects of oxycodone are appropriately assessed, your doctor may recommend combining Benadryl (diphenhydramine) for certain indications, such as insomnia. Your doctor may adjust the dose of one of the medications to get the best response in a safe way.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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