Taking Amlodipine With Melatonin
There combination is generally considered safe to take.
Is it safe to take amlodipine and melatonin together? I have been on amlodipine for 5 years and wanted to start taking melatonin at night to help sleep.
Most online 'interaction checker' tools will return no drug interaction between melatonin and amlodipine. They are generally considered safe to take together but there are a couple of potential issues to be aware of.
First is the fact that amlodipine, being a blood pressure medication, can cause dizziness, sedation and lightheadedness. Therefore, taking at the same time as melatonin could theoretically increase sedation.
Nevertheless, since you are most likely taking melatonin at bedtime, additive sedative effects from both medications would be mitigated as you are trying to fall asleep.
Secondly, some studies have reported that melatonin can decrease nocturnal (night-time) blood pressure.
One study found that extended-release melatonin decreases systolic blood pressure by an average 3.8-6 mmHg and diastolic blood pressure by 3.6-4 mmHg during sleeping hours after taking for four weeks.
This increases the risk of low blood pressure (i.e. hypotension), which can cause dizziness and lightheadedness. This theoretically could increase the risk of falls if you need to get up and move during the night.
If taking melatonin and amlodipine, it is important to be aware that you could get lightheaded and just be sure to get up slowly and take your time if you need to move around after taking.
Taking amlodipine and melatonin together could potentially increase sedation and lightheadedness. Nevertheless, the combination is generally considered to be safe for most.
Amlodipine is a calcium channel blocker used for the treatment of hypertension and chronic stable angina pectoris (chest pain caused by reduced blood flow to the heart).
It affects the amount of calcium found in your heart and muscle cells, which relaxes your blood vessels, reducing the amount of work the heart has to do.
Amlodipine may be taken with or without food.
Additional information regarding amlodipine can be found here:
Melatonin is hormone produced in the brain by the pineal gland and has a variety of effects on the body. It is most well-known for regulating our circadian rhythm, or sleep-wake cycle.
The synthesis and release of melatonin in the body are stimulated by darkness and suppressed by light.
The vast majority of commercial melatonin supplements are synthesized and not naturally derived from animal pineal glands due to concerns over contamination.
Melatonin is recommended to be taken 1 to 2 hours before bedtime, after, but not with, evening meal as food can delay absorption.
Additional information about melatonin can be found here:
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