Taking Aleve With Metformin

Our pharmacist discusses the potential interaction between Aleve (naproxen) and metformin.

Question

Can I take Aleve (naproxen) while taking 1000 mg of Metformin a day?

Asked by Anne On Dec 05, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Dec 08, 2017

Yes, Aleve (naproxen) may be safely taken along with Metformin at any prescribed dose. There are no reported interaction between these two drugs. Having said this, there is a general concern with taking drugs like Aleve if you have diabetes, as discussed below.


Although there are no drug-drug interaction between Aleve and metformin, long term use of NSAIDs (like Aleve) is not recommended in diabetics as they can strain and reduce kidney function. Having diabetes can also progressively worsen kidney function. Due to this, Tylenol (acetaminophen) may be a better choice if treating minor pains or a headache. Always check with your doctor before adding over the counter medications or changing medications.


Aleve is an over the counter nonsteroidal anti-inflammatory (NSAID) that can help reduce fever, treat muscle aches, toothaches, back pain, arthritis pain, headaches, and other minor aches and pain. In general, it can be taken every 8 hours, or up to 3 tablets in a 24 hour period. One shouldn't take Aleve for more than 10 days in a row due to the increased risk of side effects.


Metformin is a medication used to help treat type 2 diabetes by lowering blood sugar, and ultimately preventing organ damage. It is usually taken twice daily, for a total dose of 1000 mg to 2000 mg total. Common side effects of metformin include nausea, vomiting, diarrhea, gas, and headaches.

About the Pharmacist

Dr. Stacy Holcroft

Stacy Holcroft is retail pharmacist specializing in diabetes, heart disease, and oncology. Up to date with new drugs and research in these fields and others.

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