Taking Airborne With Benadryl (Diphenhydramine)

In our latest question and answer, our pharmacist discusses whether or not there is an interaction between Airborne & Benadryl (Diphenhydramine).

Question

If I took airborne an hour ago, can I take Benadryl (diphenhydramine) now?

Asked by Deb On Nov 26, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 26, 2017

Yes, Airborne and Benadryl (diphenhydramine) may be taken together as there is no known interaction between these two medications.


Airborne is an over the counter medication claiming to boost the immune system and is used to prevent common colds and other illnesses. Airborne consists of Vitamins (A, C, B12, Zinc, Magnesium and others), antioxidants, amino acids, electrolytes, echinacea, and a few other ingredients. When Airborne first came it out, it claimed it could prevent or reduce the risk and length of the common cold and length of colds, especially for people traveling in crowded places like subways and airports; After various class action lawsuits, Airborne changed its claims and now states it boosts immune system, which in turn should help ward off germs.


Airborne is thought to be a safe over the counter medication. Of course, people with kidney disease or any other health or medical problems should consult with their doctor before taking any over the counter medication. Some people can't metabolize vitamins properly and this could lead to problems.


Benadryl (diphenhydramine) is also an over the counter medication; It is an antihistamine that helps relieve allergy symptoms as well as some cold symptoms such as watery/itchy eyes, sneezing and runny nose. Some people also use Benadryl to prevent and treat motion sickness. Others use Benadryl to help them sleep as it is a first generation histamine blocker and first generation antihistamines cause sedation. It is therefore not recommended to drive after taking Benadryl. 


Benadryl is also considered a safe medication when taken as directed. If you are a generally healthy person, there should not be any concern taking Airborne and Benadryl together. 

About the Pharmacist

Dr. Stacy Holcroft

Stacy Holcroft is retail pharmacist specializing in diabetes, heart disease, and oncology. Up to date with new drugs and research in these fields and others.

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