Switching From Zoloft To Effexor

The pharmacist discusses strategies when switching from Zoloft to Effexor.


I have been on Zoloft for 18 years. First 5 years was 50 mg then to 100 mg the remaining years. The doctor wants me to switch over to Effexor 37.5mg. Shouldn't I ween some from Zoloft? When I tried to get off of Zoloft years ago, it was a terrible time, thus it is the only reason I got back on it. Thank you.

Asked by Zandra On Aug 08, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Aug 08, 2018

There are multiple strategies that can be used when switching from one antidepressant to another.

Fortunately, there are many studies and guidelines that have evaluated how to safely change antidepressants as it is a common need. It has been reported that over two-thirds of patient don't achieve remission on their first medication, necessitating a switch (1).

Switching From Zoloft To Effexor


It is important to note that there is no 'single' recommended way to safely switch from Zoloft (sertraline) to Effexor (venlafaxine). A variety of methods can be used, including (2):

  • Direct switch
  • Cross-taper
  • Taper with wash-out switch

A direct switch refers to:

  • Your current antidepressant being stopped, with your new antidepressant initiated the next day.

A cross-taper refers to:

  • Your current antidepressant is gradually reduced and stopped.
  • The new antidepressant is started at a low dose at some point during the taper of the first antidepressant. This means you will be taking both antidepressants at the same time.
  • The dose of the second (new) antidepressant is increased slowly to the therapeutic dose while the first (old) antidepressant is slowly decreased and discontinued.

A taper with wash-out switch refers to:

  • The first antidepressant is gradually reduced and stopped.
  • This is followed by a 'drug-free' interval, which can last for several days to several weeks. This allows time for the old antidepressant to leave your system.
  • After the wash-out period, the new antidepressant is started according to its dose recommendation.

The strategy employed depends on several factors, and each has positives and negatives.

For example, the 'taper with washout' method is the most conservative and likely the safest in terms of adverse drug reactions but increases the risk of symptom recurrence of the condition being treated.

A 'direct switch' is the easiest to employ and can be effective when switching to an antidepressant with a similar mechanism of action. However, there is a small increase in risk of adverse drug effects.

Zoloft To Effexor Recommendations

All of the above tapering methods have been used when switching from Zoloft to Effexor. Most studies don't specifically state a Zoloft to Effexor switch, but rather a more general SSRI (the class which contains Zoloft) to Effexor switch.

Studies published the New England Journal of Medicine and Journal of Clinical Psychology have reported using the 'direct switch' method safely and effectively (3, 4). In both studies:

  • The initial SSRI agent was stopped, with Effexor initiated the next day.

A different study recommends that if you are on a high dose of your SSRI, then it may be safer to taper it down before starting on Effexor, to avoid side effects (5).

To reiterate, there isn't one recommended method when switching from Zoloft to Effexor. The method employed depends on many factors and should be based on a discussion with your doctor.

The method your doctor is recommending isn't uncommon, especially since Effexor has serotonin effects, like Zoloft. In addition, when employing a 'direct switch' method, the new agent is typically started at a low dose, which 37.5 mg of Effexor is. Be sure to talk with your doctor regarding your concerns and options.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

About Zoloft (Sertraline)

Zoloft (sertraline) (pronounced SER tra leen) is used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD) or social anxiety. It is classified as a SSRI, selective serotonin re-uptake inhibitor, which work by increasing the availability of serotonin in the brain as well as changing the balance of serotonin receptors over time. Zoloft may be taken without regard to meals in the morning or evening. Like many antidepressants, full effects of the drug may not be realized for 6-8 weeks.

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