Splitting Toprol XL (Metoprolol Succinate)

In our latest question and answer, the pharmacist discusses splitting metoprolol succinate (Toprol XL).

Question

I split a metoprolol succinate and then split the half and took that in an attempt to ween myself off of it. Now I'm scared that I may have done the wrong thing and it could harm me.... help please.

Asked by Arlie On Jun 22, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jun 22, 2018

Metoprolol Succinate TabletsMost extended release medications (e.g. XL, CR, SR,or XR in its name) may not split, but there are exceptions. Metoprolol Succinate (Brand name Toprol XL) is one of these exceptions and you may split it one time. The ability to split Toprol XL comes from the unique way that the medication and its approved generics are formulated.


Most extended release medications are composed of a coating around the active ingredient of the medication. Through a wide variety of mechanisms, this coating regulates how fast a drug is released into your system for absorption by the body. If this outer coating is split, it can cause the drug to be released all at once. If this occurs, it could vastly compromise the effectiveness of the medication, lead to potentially serious side effects and even cause an overdose.


Splitting Toprol XL

Toprol XL and its approved generics are composed of a unique micropellet design in which many small coated pellets are dispersed evenly throughout the larger tablet. These individual micropellets act similar to a conventional extended release tablet and control the release of Metoprolol once the larger tablet is in the GI tract. Due to how Toprol XL is formulated, it may be safely split one time.


Although it is ok to split Toprol XL one time (the tablet is scored to aid you in this) you should not crush, chew, or split the tablet more than 1 time. Any of these actions can damage the micropellets and disrupt the intended release of the medication.


Tapering Toprol XL

Whether or not beta-blockers, such as Toprol XL, need to be tapered depends on the individual and other factors (such as how long you have been taking the medication). Sudden withdrawal, or stopping beta-blockers cold turkey, has been associated with certain side effects such as:

  • Angina
  • Heart attack
  • Arrhythmias
  • Fast heart rate
  • Low blood pressure


Although sources vary, for some patients it is recommended to taper over one to two weeks before discontinuing completely. Some patients may need to be tapered over longer periods of time, for as long as three weeks. If withdrawal symptoms do occur while tapering, it may be prudent to reinstate therapy, at least for a short period of time.


It is important to always communicate with your doctor regarding tapering your medication as you can discuss the most appropriate way to discontinue it in your specific situation. You should not discontinue Toprol XL without speaking with your doctor first.

About the Pharmacist

Dr. Adam DeRue Pharm.D

Dr. Adam DeRue is a Doctor Of Pharmacy and registered pharmacist.

About Toprol XL (Metoprolol Succinate)

Toprol XL (metoprolol succinate) is classified as a "beta-blocker", specifically a beta-1 selective adrenergic antagonist. It is used for a variety of indications including high blood pressure (hypertension), post heart attack (myocardial infarction) and migraine prophylaxis. Toprol XL is typically dosed once to twice daily and should be given with food or immediately after food to enhance absorption. Unlike most extended release products, Toprol XL can be safely cut or split one time as the active ingredient (metoprolol) is contained in "micropellets", evenly distributed throughout the tablet. It should not be crushed however as this will ruin the extended release properties of the medication.

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