In most cases, it is recommended that you use pain relievers other than ibuprofen (Advil) or naproxen (Aleve) when taking sertraline (Zoloft), to avoid potential interactions and side effects. Tylenol is typically the preferred option.


Tylenol is in a different class of pain reliever than the non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen and it does not work to relieve pain in the same way. Due to the different mechanism of action, Tylenol does not interact with selective serotonin reuptake inhibitors (SSRIs) like sertraline.


An analysis of several studies shows there is a significant increase in the risk of bleeding (mostly stomach bleeds) when NSAIDs (like Aleve and Advil) and SSRIs are taken together. In fact, SSRIs and NSAIDs alone have been shown to cause a risk for bleeding. Adding them together only increases the risk.


When taking NSAIDs and SSRIs in combination, studies have shown anywhere from a 2.8-fold to 15.6-fold increase in stomach bleeds. If taking a combination of NSAIDs and SSRIs, it is recommended to monitor for signs and symptoms of bleeding.


When To Take Zoloft

Generally, it is recommended to take medication around the same time of day so there is consistency. This can help people to remember to take their medication every day. It is also important for medications like Zoloft to be taken around the same time of day to keep the levels of the drug consistent in the body since it is altering serotonin levels. Taking it at the same time each day will help it be fully effective.


Although rare, some patients may start to experience symptoms such as:

  • Irritability
  • Agitation
  • Dizziness
  • Anxiety
  • Confusion
  • Headache
  • Lethargy
  • Insomnia


These symptoms may be experienced more if the Zoloft is stopped abruptly, which is why it is important to be weaned off if stopping. If missing a dose, it is recommended to take the dose as soon as you remember unless it is close to the timing of the next one. It is not recommended to take two doses at the same time.


It is up to you regarding what time of day to take the Zoloft. Many people base this on potential side effects, mainly either drowsiness or restlessness. It is recommended to take it in the morning if it makes you feel restless. It is recommended to take it at night if it makes you feel drowsy. This depends on how it affects you and when you feel it would be best for you to take and when you feel you will remember best.


Alternative Pain Relivers

Aside from Tylenol, you can feel safe using most topical pain relievers with Zoloft, like Tiger balm, Bengay and lidocaine patches. These will not interact with it.