Prednisone, Buspar And Clonazepam Questions

The pharmacist discusses several questions relating to prednisone, buspirone and clonazepam.


Can you take prednisone, buspar, and clonazepam together? And what is the best way to wean off clonazepam .5mg for 2 months? And does buspar cause insomnia? Thxs

Asked by Angela On Jul 15, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 17, 2018

There is a potential interaction between clonazepam and Buspar (buspirone).

Clonazepam may cause additive sedative, CNS, and/or respiratory-depressant effects with buspirone. However, it is common for patients to overlap anxiety treatment when switching from benzodiazepines, like clonazepam, to buspirone. It is important to note that buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy.

In most cases, before starting therapy with buspirone, it is prudent to withdraw gradually from clonazepam (i.e. taper). Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect.

There are no interactions with the prednisone.

In regard to your other questions:

  • Tapering Clonazepam: When tapering medication, it is important to discuss your options with your doctor as there are many factors to consider when picking an appropriate tapering method. In general, most benzodiazepines are slowly tapered by a dose decrease of 10-25% every week and adjust based on tolerability.
  • Buspar Causing Insomnia: Although insomnia did not occur more frequently than placebo in clinical trials (3% each), it was among the CNS effects associated with discontinuation of treatment in some patients.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Buspar (Buspirone)

Buspar (Buspirone) is an anxiolytic (i.e. anti-anxiety) medication that is structurally and pharmacologically distinct from benzodiazepines, such as Valium and Xanax. Buspar does not impair psychomotor function, and does not cause physical dependence, an advantage over the use of benzodiazepines. Buspar also tends not to cause significant sedation. Buspar is not to be used for immediate effects, as consistent dosing of 2 weeks or longer is sometimes needed for onset of anxiolytic effects.

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