Melatonin Interaction With Citalopram

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between the melatonin contained in ZzzQuil Pure Zzzs and Celexa (citalopram).


Is it safe to take Pure Zzzs gummies while taking citalopram?

Asked by Dom On Jul 20, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 21, 2018

ZzzQuil Pure Zzzs contains melatonin as the active ingredient, so when it comes to potentially interactions, that is what we should be concerned with.

Having said that, there is no known interaction between melatonin and citalopram. They are considered safe to take together.

Melatonin only has one known interaction with an antidepressant, and that is with Luvox (fluvoxamine). In fact, some studies reported that co-administration of the two can increase melatonin levels over 20-fold due to the potential for Luvox to inhibit the metabolism of melatonin. This has not been shown to happen with citalopram, as it is metabolized via a different enzyme.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Celexa (Citalopram)

Citalopram is a selective serotonin reuptake inhibitor (SSRI), most commonly used to treat major depression in adults. It is also used off-label for premenstrual dysphoric disorder (PMDD), hot flashes, and anxiety disorders. Unlike most other SSRIs, citalopram has no FDA-approved indications in children. Citalopram can be taken with or without food, but food may increase tolerability. In general, it can take up to 4 to 6 weeks to notice the effects citalopram. Citalopram was approved by the FDA for the treatment of depression in adults in July 1998. The FDA approved an oral solution in December 1999 and an orally disintegrating tablet formulation in December 2005.

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