Lexapro (Escitalopram) With Phenylephrine Interaction

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Lexapro (escitalopram) and phenylephrine.


Can I take Lexapro with Phenylephrine HCI? This is the only thing that seems to work for me when I have sinus pain and congestion. Thank you for your time.

Asked by Julie On Jul 25, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 25, 2018

There is no drug interaction between Lexapro (escitalopram) and phenylephrine. They are considered safe to take together.

However, it is important to note that phenylephrine (a nasal decongestant) is a component in a many over the counter combination ingredient cold/cold products. Some of these products contain medication that generally should not be used with Lexapro, such as dextromethorphan (increasing the risk of serotonin syndrome). Always be sure to look at labels of the medication you are purchasing.

As stated above, phenylephrine as a single ingredient is considered safe to use with Lexapro. It is available in the brand name product Sudafed PE and generically as well.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

About Lexapro (Escitalopram)

Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) and is most commonly used for the treatment of depression. It is also used off-label for the treatment of anxiety disorders. Escitalopram is the active enantiomer of citalopram, and is generally thought to exert its antidepressant effects more quickly than citalopram. While effective, Lexapro, and all SSRI medications, is associated with a variety of potential side effects including weight fluctuations (gain and loss), headache, dizziness, QT prolongation and sexual dysfunction. Lexapro can be taken with or without food. If nausea occurs, administer after a meal.

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