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Is There An Interaction Between Pepcid And NyQuil?

The pharmacist discusses whether or not there is a drug interaction between NyQuil and Pepcid.


Do NyQuil and Pepcid AC have an interaction or am I able to take both around the same time?

Asked by Flakkita_23 On Sep 24, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 25, 2019
NyQuil bottle on bathroom counter


There is no known drug interaction between Pepcid (famotidine) and NyQuil, they are considered safe to take together.

It is important to remember that NyQuil is a 'combination ingredient' products, and contains three different drugs (the 'Severe' formula contains four). These drugs are:

None of these drugs are known to interact with Pepcid. They can safely be taken at the same time.

As a final note, Pepcid can be taken with or without food and with most other medications. The prescribing information for the drug states the following:

Bioavailability [the rate and extent of absorption] may be slightly increased by food, or slightly decreased by antacids; however, these effects are of no clinical consequence.

Be sure to let us know if you have any additional questions!

We are always more than happy to help.


  • There is no known drug interaction between Pepcid (famotidine) and NyQuil.

  • References
    1. Pepcid Prescribing Information. AccessFDA
    2. H2 Blockers. StatPearls

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