Is There An Interaction Between Norco And Advil?

We answer our latest question regarding whether or not there is an interaction between Norco And Advil.


Is there an interaction between Norco and Advil?

Asked by Angela99 On Sep 22, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 22, 2017

Norco (hydrocodone/acetaminophen) has no interaction when taken with Advil (ibuprofen).

Norco is a combination of two products,hydrocodone (which is known as an opioid and is similar to morphine and codeine), and acetaminophen, which is the active ingredient in Tylenol. Ibuprofen, the active ingredient in Advil, is known as an NSAID (non-steroidal anti-inflammatory drug). While Advil produces anti-inflammatory effects that the Norco does not, it typically is not quite as effective as a pain medication as the Norco is.

Many times doctors will prescribe both together because of their different mechanisms of action and different effects on the body. You can feel confident there is no interaction between the two. All we recommend is that you take both with food and be sure to drink a full glass of water with each.

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor Of Pharmacy degree in 2010. He has been featured in several publications including the Huffington Post as well as a variety of health and pharmacy related blogs. Please feel free to reach out to him directly if you have any questions or want to connect! [email protected]; Office: 716-389-3076


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