Is The Second Shingrix Shot Different From The First?

In our latest question, the pharmacist discusses the Shingrix vaccine and how both doses contain the exact same ingredients.

Question

Is the second shot different from the first or are the two shots the same, just given two months apart? In other words, could a person get the first shot twice by mistake?

Asked by Peter On Feb 18, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 18, 2019
Shingrix Packaging With Both Vials

Overview

Shingrix is given as a two-shot series, separated by 2 to 6 months per CDC (Centers for Disease Control) recommendations as this elicits the optimal immune response against the varicella-zoster (i.e. shingles) virus.

The first and second doses of Shingrix are exactly the same. There is no difference between them. Therefore, it is impossible to get the first shot "twice" by mistake.

In fact, Shingrix is only manufactured as one product. In other words, there isn't any packaging or mark on the vials stating 'dose one' and 'dose two'.


Shingrix Ingredients

The Shingrix vaccine (both doses) comes as two vials that must be reconstituted prior to injection.

  • One vial contains a single-dose of the lyophilized varicella-zoster virus surface glycoprotein E (gE) antigen component (appears as a white powder).
  • The other vial contains an adjuvant suspension (appears as opalescent, colorless to pale brownish liquid). As a side note, an adjuvant is a component that enhances the immune response). The adjuvant in Shingrix is AS01B.

To reconstitute Shingrix, the adjuvant suspension component is transferred via syringe into the lyophilized gE antigen component vial. The resulting reconstituted suspension contains the following components:

  • Recombinant gE antigen
  • MPL (3-O-desacyl-4’- monophosphoryl lipid A)
  • QS-21 (saponin purified from plant extract Quillaja saponaria Molina)
  • Sucrose (as a stabilizer)
  • Sodium chloride
  • DOPC (dioleoyl phosphatidylcholine)
  • Potassium dihydrogen phosphate
  • Cholesterol
  • Sodium dihydrogen phosphate dihydrate
  • Disodium phosphate anhydrous
  • Dipotassium phosphate
  • Polysorbate 80

Shingrix does not contain preservatives and the total volume injected intramuscularly is 0.5 mL.

If you have any further questions about Shingrix, be sure to ask one of our pharmacists or check out our previously answered questions regarding it!


Answer Summary

Both Shingrix doses (with administration separated by 2 to 6 months) are exactly the same product. It is not possible to accidentally give or get them out of order.

References

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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