Is It Safe To Take ZzzQuil And Tamiflu Together?

There is no known drug interaction between Tamiflu and ZzzQuil. They are safe to take together.


Can I take ZzzQuil with Tamiflu?

Asked by Curious jo On Mar 19, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Mar 19, 2019
Tamiflu ZzzQuil Text Over Tamiflu Blister Packed Capsules

Is There An Interaction Between ZzzQuil And Tamiflu?

There is no known drug interaction between ZzzQuil and Tamiflu. They are considered safe to take together.

Your doctor or pharmacist may even recommend using both together to help manage some of the symptoms you may be experiencing from the flu (which Tamiflu is used to treat).

ZzzQuil For Flu Symptoms

Having the flu can cause a variety of symptoms, including headache, tiredness, insomnia, body aches and a runny nose to name a few.

ZzzQuil may be a good option for an over the counter medication to help treat some of the symptoms the flu may cause.

It contains the active ingredient diphenhydramine, which is also the active ingredient in Benadryl.

Diphenhydramine is classified as a 'first-generation' antihistamine and will not only help to clear up a runny nose and watery eyes but will also make you tired (which is why it is used in ZzzQuil).

ZzzQuil With Tamiflu

Tamiflu (oseltamivir) can be taken with or without food and can be taken at the same time as most other medications.

In fact, the prescribing information for Tamiflu only lists two known drug interactions:

  • Live flu vaccine
  • Probenecid

It shouldn't be used with a live flu vaccine as it can reduce the effectiveness of it.

When used with probenecid, Tamiflu concentrations can be increased, but even then, the prescribing information states that it has such a wide safety margin, the drugs can be used together with no adjustment in dosing.

As stated previously, there is no known interaction with ZzzQuil and they can be used together. This goes for most other drugs that contain diphenhydramine as well, including Benadryl and Tylenol PM (acetaminophen; diphenhydramine).

Answer Summary

There is no known interaction between ZzzQuil (which contains diphenhydramine) and Tamiflu.


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