Is Hordenine A Banned Substance?

We answer our latest question regarding the supplement hordenine as whether or not it is a banned substance,

Question

20 hours before i had taken a drugs test, I took a pre workout supplement before i went to the gym, which contained hordenine hci. It is a military test. Will I fail for hordenine being in the supplement, as I know it replaced DMAA which the FDA recently banned...

Asked by Roy On Sep 29, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Sep 29, 2017
As far as I'm aware, hordenine is not a banned substance for the military. I don't even believe it is a banned substance by the anti-doping agency. Hordenine is a component of many different kinds of plants, most notably, barley. 


Hordenine is considered a sympathomimetic type supplement meaning that it stimulates the sympathetic nervous system. It mimics many actions of our naturally occurring neurotransmitters such as epinephrine and dopamine. Sympathomimetics have a variety of uses including a feeling of energy/explosiveness, heightened alertness, increased metabolism etc...


Again, hordenine is a naturally occurring substance that many people consume in small amount from their normal diet. Recently, it has been isolated and touted as a work out or weight loss aid.While the benefits for this use aren't well studied, hordenine appears to be fairly safe and well tolerated. I should mentioned however that according to some research, hordenine,  may yield false positive results on tests fos for various opiate drugs. This doesn't appear to be common however.


DMAA was a synthetic drug that was invented and manufactured by the drug company Eli Lilly. Over time, it was realized that the drug when used for recreational and supplemental purposed, was fairly unsafe and was thus discontinued. Hordenine may not be quite as effective, but it appears to be much safer.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

Recent Questions