Is Benadryl Harmful To The Kidneys?

Benadryl (diphenhydramine) isn't known to reduce kidney function but has been reported to cause damage in rare cases.


I was wondering if Benadryl can be harmful to the kidneys? I take it a few times a week for allergies or to help me sleep.

Asked by George On Nov 01, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 01, 2018
Kidney Title


Although there have been a few case reports of Benadryl (diphenhydramine) induced kidney damage, they have only been in cases of overdose and in those with certain pre-existing conditions. It is generally considered to be safe and non-damaging to the kidneys. 

In fact, most literature suggests that no dosage adjustments are required in those with reduced kidney function or impairment (1, 2)

Benadryl - Kidney Damage

Benadryl (diphenhydramine) is a first-generation, sedating antihistamine of the ethanolamine class. It is available in a variety of dosage forms, including:

  • Oral
  • Topical
  • Parenteral (e.g. IM injection)

While Benadryl is excreted renally (i.e. via the kidneys), it is extensively metabolized in the liver and metabolism speed may be reduced in the presence of hepatic impairment. Dosage reduction may be required in these individuals.

In terms of Benadryl damaging the kidneys, there have been a few case reports, but have typically only occurred in cases of overdose.

One such case study involved an individual who intentionally overdosed on Benadryl and alcohol, and was diagnosed with acute renal failure and subsequently suffered from rhabdomyolysis.

Another study noted that Benadryl, or any drug that has significant anticholinergic properties, can cause urinary retention and therefore increase the risk of renal kidney injuries in those with pre-existing disease (3):

"Anticholinergic medications, such as diphenhydramine [Benadryl], can cause postrenal obstruction (blockage of the urinary tract). Obstruction can occur from the urinary tubule to the urethra, resulting in urine accumulation and ultimately increasing upstream pressure and decreasing GFR [Glomerular Filtration Rate]."

Since Benadryl can cause urinary retention (especially in the elderly or in those with pre-existing kidney disease), it is recommended to be used cautiously in individuals with bladder obstruction or urinary retention. This is a generally precaution with any drug that has anticholinergic effects.


  • Benadryl is not known to reduce kidney function but has been reported (in rare case reports) to cause injury to the kidneys in cases of overdose or in those with pre-existing disease (e.g. bladder obstruction, urinary retention).

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Benadryl (Diphenhydramine)

Benadryl (diphenhydramine) is a first generation, sedating antihistamine (H1-blocker) of the ethanolamine class. It is available in oral, topical, and parenteral product forms. Benadryl is well known to cause significant sedation in most individuals and is commonly used in night-time sleep aids. Benadryl also has potent "drying" effects in most patients, which is why is causes dry mouth, dry eyes and constipation. The onset of action of Benadryl is around 15-30 minutes after taking by mouth, with peak effects occurring 1 to 3 hours later. The duration of action is around 4 to 6 hours, with this being prolonged in the elderly and in those with liver disease.

Recent Questions