Interaction Between Yaz And MSM (Methylsulfonylmethane)

In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between MSM (Methylsulfonylmethane) and Yaz.


Hi, I am taking Yaz birth control. Can I take a MSM pill with it or does it affect the efficacy of the pill?

Asked by Nat On Feb 06, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 06, 2019


There are no known drug interactions between Yaz (Drospirenone; Ethinyl Estradiol) and MSM (Methylsulfonylmethane). They are considered safe to take together.

In fact, MSM isn't thought to have any significant drug interactions (aside from a potential one that is discussed further on) and the variety of studies reviewing the compound don't believe it has any impact on the metabolism or absorption of other drugs, including Yaz.

Answer Summary

MSM (Methylsulfonylmethane) has no documented interactions with birth control pills, including Yaz.

About MSM

Methylsulfonylmethane (MSM) is a naturally occurring, organic sulfur-containing compound and is one of the most purchased over the counter supplements based on sales. It is most often found in combination with glucosamine and chondroitin. You may see MSM referred to as:

  • DMSO2
  • Methyl sulfone
  • Dimethyl sulfone

In addition to supplemental MSM, it is often consumed via our regular diet, as it is found in:

  • Green plants (certain varieties such as horsetail)
  • Algaes
  • Fruits
  • Vegetables
  • Milk
  • Beer
  • Coffee
  • Tea

MSM is used as a treatment for a variety of symptoms and conditions, the most common ones being inflammation, joint dysfunction, and osteoarthritis.

How It Works

The exact mechanism of action of MSM isn't well understood, and more studies are needed to determine how effective it is in its use.

Nevertheless, research shows that doses of MSM between 1 and 6 grams daily has a statistically significant effect in reducing joint pain and swelling. Additionally, it may improve overall joint function.

Some theories into its actions suggest that MSM binds to structural components in connective tissues, which in turn which can reduce joint-cartilage degradation. Additionally, it may inhibit the expression of certain inflammatory mediators including:

  • Interleukin-1
  • Tumor necrosis factor-alpha
  • Cyclooxygenase 2

MSM as a compound is over 33% sulfur, which is thought to be vitally important to the maintenance of connective tissues.

Side Effects

MSM is considered to be generally well-tolerated, only causing mild side effects in most. These include:

  • Nausea
  • Diarrhea
  • Bloating
  • Headache
  • Fatigue

There have been reports of allergic reactions, most likely due to the sulfur content of MSM.

Drug Interactions

MSM doesn't have any documented drug interactions. However, one study, published in the journal Osteoarthritis and Cartilage, reports that it may potentially increase the effects of anticoagulant drugs, such as warfarin. Anecdotal reports state that some individuals have experienced increased bruising or bleeding in the stool.

It is important to note that these side effects have not been confirmed in clinical studies, and more data is needed to determine the extent of any drug interaction with anticoagulants.

Part of the issue is that most clinical studies involving MSM exclude individuals who are taking anticoagulants, so data in this population is scarce. If you are taking an anticoagulant or similar 'blood-thinning' medications, be sure to speak with your doctor before using MSM.

About Yaz

Yaz is a combined hormone contraceptive, containing:

  • Drospirenone
  • Ethinyl estradiol

Drospirenone is a fourth-generation progestin and has antiandrogenic properties. Therefore, in addition to its contraceptive effects, it can be beneficial for the treatment of other conditions including:

  • Acne
  • Water retention
  • Increased appetite

One negative regarding drospirenone is that it may increase potassium levels and shouldn't be used in some individuals, such as those with kidney or liver problems.

Yaz has no documented interactions with MSM.

  • Elsevier ClinicalKey: Yaz (Accessed 2/05/19)
  • Elsevier ClinicalKey: MSM (Accessed 2/06/19)
  • Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. PubMed
  • Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. PubMed
  • The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. PubMed

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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