Interaction Between Yaz And MSM (Methylsulfonylmethane)
In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between MSM (Methylsulfonylmethane) and Yaz.
Hi, I am taking Yaz birth control. Can I take a MSM pill with it or does it affect the efficacy of the pill?
There are no known drug interactions between Yaz (Drospirenone; Ethinyl Estradiol) and MSM (Methylsulfonylmethane). They are considered safe to take together.
In fact, MSM isn't thought to have any significant drug interactions (aside from a potential one that is discussed further on) and the variety of studies reviewing the compound don't believe it has any impact on the metabolism or absorption of other drugs, including Yaz.
Answer SummaryMSM (Methylsulfonylmethane) has no documented interactions with birth control pills, including Yaz.
Methylsulfonylmethane (MSM) is a naturally occurring, organic sulfur-containing compound and is one of the most purchased over the counter supplements based on sales. It is most often found in combination with glucosamine and chondroitin. You may see MSM referred to as:
- Methyl sulfone
- Dimethyl sulfone
In addition to supplemental MSM, it is often consumed via our regular diet, as it is found in:
- Green plants (certain varieties such as horsetail)
MSM is used as a treatment for a variety of symptoms and conditions, the most common ones being inflammation, joint dysfunction, and osteoarthritis.
How It Works
The exact mechanism of action of MSM isn't well understood, and more studies are needed to determine how effective it is in its use.
Nevertheless, research shows that doses of MSM between 1 and 6 grams daily has a statistically significant effect in reducing joint pain and swelling. Additionally, it may improve overall joint function.
Some theories into its actions suggest that MSM binds to structural components in connective tissues, which in turn which can reduce joint-cartilage degradation. Additionally, it may inhibit the expression of certain inflammatory mediators including:
- Tumor necrosis factor-alpha
- Cyclooxygenase 2
MSM as a compound is over 33% sulfur, which is thought to be vitally important to the maintenance of connective tissues.
MSM is considered to be generally well tolerated, only causing mild side effects in most. These include:
There have been reports of allergic reactions, most likely due to the sulfur content of MSM.
MSM doesn't have any documented drug interactions. However, one study, published in the journal Osteoarthritis and Cartilage, reports that it may potentially increase the effects of anticoagulant drugs, such as warfarin. Anecdotal reports state that some individuals have experienced increased bruising or bleeding in the stool.
It is important to note that these side effects have not been confirmed in clinical studies, and more data is needed to determine the extent of any drug interaction with anticoagulants.
Part of the issue is that most clinical studies involving MSM exclude individuals who are taking anticoagulants, so data in this population is scarce. If you are taking an anticoagulant or similar 'blood thinning' medications, be sure to speak with your doctor before using MSM.
Yaz is a combined hormone contraceptive, containing:
- Ethinyl estradiol
Drospirenone is a fourth-generation progestin and has antiandrogenic properties. Therefore, in addition to its contraceptive effects, it can be beneficial for the treatment of other conditions including:
- Water retention
- Increased appetite
One negative regarding drospirenone is that it may increase potassium levels and shouldn't be used in some individuals, such as those with kidney or liver problems.
Yaz has no documented interactions with MSM.
- Elsevier ClinicalKey: Yaz (Accessed 2/05/19)
- Elsevier ClinicalKey: MSM (Accessed 2/06/19)
- Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. PubMed
- Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. PubMed
- The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. PubMed
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