Interaction Between Clindamycin and Methadone

In our latest question and answer, our pharmacist discusses the potential interaction between clindamycin and methadone.


Can I take methadone 50mg with Clindamycin 300 mg?

Asked by Dukk On Dec 06, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Dec 06, 2017

There is a potentially serious interaction between clindamycin and methadone, but overall, it is rare.

Clindamycin may potentiate the effects of opioid agonists, which includes methadone. This could potentially increase the risk of respiratory depression. It is important to note that this interaction is uncommon and has mostly been reported via case studies such as this one.

The proposed mechanism behind the interaction is as follows. Clindamycin, in addition to its antibacterial effects, can cause neuromuscular blockade, resulting in paralysis of the affected muscle. As opioid drugs can depress respiratory function, any additional paralysis to the muscles responsbile for respiration could be serious.

As mentioned, this interaction isn't necessarily considered a major one since it appears to be rare. Nevertheless, the potential side effect should be considered, especially if you are on multiple opioids, taking high doses or are undergoing anesthesia with the use opioids.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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