How Long Does One Dose Of Amoxicillin Stay In Your System?

In our latest question and answer, the pharmacist discusses how long one dose of amoxicillin lasts in your system.


How long does amoxicillin stay in your system?

Asked by Brian On Jul 31, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Aug 01, 2018

We have written a few articles on this subject, which can be found here:

Below are some highlights from that article:

  • Amoxicillin has a short half-life relative to other drugs, around 1 to 1.5 hours. 'Half-life' refers to the time it takes our bodies to metabolize 50% of a drug.
  • Most of your amoxicillin dose will be eliminated within 12 hours (this is why it needs to be dosed 2-3 times daily). More than 60% will be eliminated via the urine 6 hours after your last dose.
  • Elimination time can be prolonged in patients with kidney disease. There are reports that the half-life of amoxicillin is extended to over 12 hours in those with end-stage kidney disease.
  • Amoxicillin will last longer in pediatric patients less than 12 weeks of age due to incompletely developed renal function.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Amoxicillin

Amoxicillin is an semisynthetic "aminopenicillin" similar to ampicillin and penicillin. It does however, have a broader spectrum of antibacterial effects than penicillin and is better absorbed than ampicillin. Amoxicillin is used to treat a variety of infections including: Otitis media, bronchitis, sinusitis, and bacterial cystitis. In general, amoxicillin can be given with or without food but food may reduce any gastrointestinal side effects.

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