How Long Does Benadryl Last In Children?

In our latest question and answer, the pharmacist discusses how long a dose of Benadryl lasts in children.


My 7-year-old has been miserable with allergies. I gave her 7 mL of Benadryl and it didn't work so I gave her Zyrtec 7mL four hours later. After about 30 min she was totally asleep (it was also bedtime). I'm a little concerned. I know not to give them at the same time. Was 4 hours was long enough to wait for the Benadryl to be wearing off? I keep going and checking on her.

Asked by lmw2 On May 03, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 04, 2019
Pink tablets In Blister Pack - Benadryl In Children Text


The effects of Benadryl last on average 4 to 6 hours in both children and adults.[1]

However, multiple studies report that children do metabolize it more quickly, and therefore, the duration of action tends to be on the lower end of the range (around four hours).

Interestingly, this faster metabolism in children increases the rate of a side effect we don't typically associate with Benadryl.

Children have a far higher rate of what is known as 'paradoxical excitation'. While we typically expect Benadryl to cause sedation since it is a sedating first-generation antihistamine, this doesn't always occur in children. The prescribing information for Benadryl products warn of this:[2]

As in adults, antihistamines may diminish mental alertness in pediatric patients. In the young pediatric patient, particularly, they may produce excitation.

In terms of giving Benadryl with Zyrtec, using both can increase the risk of certain side effects (like sedation and dizziness). Nevertheless, giving Zyrtec 4 hours after giving Benadryl to a child won't likely cause too much trouble as most of the Benadryl dose is likely to be already metabolized.

Children Metabolize Benadryl Faster

As mentioned above, studies consistently show that Benadryl is metabolized more quickly in children than in adults.

Not only is it cleared from the body more quickly in children, the half-life of the drug (which is the time it takes to metabolize 50% of a drug) is also shorter.

One study reported the following numbers in regard to Benadryl clearance (the rate at which a drug is removed from the plasma) and half-life:[3]

  • Half-Life
    • Elderly: 13.5 hours
    • Adults: 9.5 hours
    • Children: 5.4 hours
  • Clearance
    • Elderly: 11.7 mL/min/kg
    • Adults: 23.3 mL/min/kg
    • Children: 49.2 mL/min/kg

Since children metabolize Benadryl faster than adults, it makes sense that its duration of action would be shorter.

Additionally, since Benadryl is cleared more slowly in the elderly, that would account for the fact that it is known to cause more sedation and dizziness in that age group:

Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.

Excitation In Children

An interesting characteristic of Benadryl is that it is known to cause 'paradoxical excitation' in children (as opposed to sedation).

While the exact mechanism as to why this occurs isn't well understood, it appears to be that the faster metabolism of Benadryl in children increases the concentrations of an 'excitatory' metabolite.

One study reported that individuals classified as 'ultrarapid metabolizers' of Benadryl (due to an increased concentration of the CYP2D6 metabolizing enzyme) had an increased risk of the excitatory side effects.

Therefore, since we know that children also metabolize Benadryl more quickly than other patient populations, an increased concentration of the excitatory metabolite could be the reason excitation occurs in some. [4]

Final Words

The published duration of action for Benadryl is essentially the same for both children and adults (around four to six hours) but we do know that children clear it from their system more quickly.

In your situation, giving Zyrtec just a few hours after Benadryl, it may increase the risk of sedation or other side effects, but aside from that, it shouldn't cause many issues.

Only cases of extreme antihistamine overdose have resulted in severe side effects (such as hallucinations and shallow breathing).[5]


Benadryl lasts around 4 to 6 hours per dose in children, which is similar to the duration of action in adults. However, multiple studies show that children metabolize Benadryl faster than adults.

  1. ^ Elsevier ClinicalKey: Benadryl Monograph. ClinicalKey
  2. ^ Diphenhydramine Prescribing Information. AccessFDA
  3. ^ Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. PubMed
  4. ^ Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. PubMed
  5. ^ Dose-dependent toxicity of diphenhydramine overdose. PubMed

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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