Guaifenesin With Cetirizine

There is no drug interaction between them.


Can I take Mucinex with the allergy medication Zyrtec?

Asked by Chamy On Nov 26, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 26, 2018


It is safe to take cetirizine (active ingredient in Zyrtec) and Guaifenesin (active ingredient in Mucinex) together. There is no interaction between them.

In fact, it is fairly common to take the combination as they each help to treat different symptoms.

Cetirizine, a 'second-generation' antihistamine, is effective for treating many of the symptoms we associate with allergies or colds, including:

  • Sneezing
  • Runny nose
  • Watery eyes
  • Itching
  • Redness

Guaifenesin is an expectorant, helping to clear chest congestion and thin mucus secretions.

Cetirizine and guaifenesin can have synergistic effects.

Cetirizine can help to 'dry' mucus secretions, due to the anticholinergic effects of the drug. This can aid in reducing or helping to expectorate thick mucus that feels as though it is 'stuck' in your chest and airway.

Guaifenesin is generally very well tolerated and has few side effects or interactions. Nausea, drowsiness, dizziness, and headache occur rarely at recommended doses of guaifenesin.

Cetirizine may cause drowsiness in some individuals, but this effect should not be exacerbated by the addition of guaifenesin.

Section Summary
There is no interaction between guaifenesin and cetirizine. They are safe to take together.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

Recent Questions